SML1596
PPZ2
≥98% (HPLC)
Synonym(s):
2-[4-(2,3-Dimethylphenyl)piperazin-1-yl]-N-(2-ethoxyphenyl)acetamide, 4-(2,3-Dimethylphenyl)-N-(2-ethoxyphenyl)-1-piperazineacetamide
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About This Item
Empirical Formula (Hill Notation):
C22H29N3O2
CAS Number:
Molecular Weight:
367.48
UNSPSC Code:
12352200
NACRES:
NA.25
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
Biochem/physiol Actions
PPZ2 selectively activates DAG-activated TRPC3/TRPC6/TRPC7 channels. PPZ2 activates native TRPC6-like channels in smooth muscle cells isolated from the rabbit portal vein. PPZ2 induces BDNF-like neurite growth and neuroprotection in cultured neurons.
TRPCs are cation channels, mainly permeable to Ca2+ ions. TRPC6 plays a crucial role in tumor development. TRPC3 controls fibronectin expression, thereby regulating wound healing process. TRPC7 is involved in the proliferation of osteoblasts.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Scientific reports, 5, 11620-11620 (2015-06-26)
Wound healing process is a complex and highly orchestrated process that ultimately results in the formation of scar tissue. Hypertrophic scar contracture is considered to be a pathologic and exaggerated wound healing response that is known to be triggered by
Chang Zeng et al.
Molecular neurobiology, 52(1), 562-572 (2014-09-13)
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Cell proliferation, 40(6), 849-865 (2007-11-21)
Bone tissue in the adult is continuously being remodelled, and overall bone mass is maintained constant by the balance between osteoclastic bone resorption and osteoblastic bone formation. Adequate osteoblastic proliferation is essential for both appropriate formation and for regulation of
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