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Safety Information

SML1405

Sigma-Aldrich

MS37452

≥98% (HPLC)

Synonym(s):

1-(2,3-Dimethoxybenzoyl)-4-[(3-methylphenoxy)acetyl]-piperazine (9CI), 1-[4-(2,3-Dimethoxybenzoyl)-1-piperazinyl]-2-(3-methylphenoxy)-ethanonemethylphenoxy)acetyl]-piperazine (9CI)

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About This Item

Empirical Formula (Hill Notation):
C22H26N2O5
CAS Number:
423748-02-1
Molecular Weight:
398.45
MDL number:
MFCD03134667
UNSPSC Code:
12352200
PubChem Substance ID:
329825852
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 20 mg/mL, clear

shipped in

wet ice

storage temp.

−20°C

SMILES string

O=C(COC1=CC(C)=CC=C1)N2CCN(C(C3=CC=CC(OC)=C3OC)=O)CC2

InChI

1S/C22H26N2O5/c1-16-6-4-7-17(14-16)29-15-20(25)23-10-12-24(13-11-23)22(26)18-8-5-9-19(27-2)21(18)28-3/h4-9,14H,10-13,15H2,1-3H3

InChI key

LUMCNRKHZRYQOV-UHFFFAOYSA-N

Biochem/physiol Actions

MS37452 is a selective Chromobox homolog 7 (CBX7) modulator that disrupts CBX7ChD binding to H3K27me3. MS37452 inhibits CBX7 binding to INK4/ARF gene locus, and induces decline of p14/ARF and p16/INK4a in human PC3 cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML1405-BULK:
SML1405-5MG:
SML1405-VAR:
SML1405-25MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Chunyan Ren et al.
Chemistry & biology, 22(2), 161-168 (2015-02-11)
Chromobox homolog 7 (CBX7) plays an important role in gene transcription in a wide array of cellular processes, ranging from stem cell self-renewal and differentiation to tumor progression. CBX7 functions through its N-terminal chromodomain (ChD), which recognizes trimethylated lysine 27

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