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Safety Information

SML1356

Sigma-Aldrich

Sephin1

≥95% (HPLC)

Synonym(s):

(E)-2-(2-Chlorobenzylidene)hydrazinecarboximidamide, Sephin 1

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5 MG
€886.00
10 MG
€1,690.00

€886.00


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5 MG
€886.00
10 MG
€1,690.00

About This Item

Empirical Formula (Hill Notation):
C8H9ClN4
CAS Number:
Molecular Weight:
196.64
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

€886.00


Please contact Customer Service for Availability

Request a Bulk Order

Quality Level

Assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

NC(N/N=C/C1=CC=CC=C1Cl)=N

InChI

1S/C8H9ClN4/c9-7-4-2-1-3-6(7)5-12-13-8(10)11/h1-5H,(H4,10,11,13)/b12-5+

InChI key

PDWJALXSRRSUHR-LFYBBSHMSA-N

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This Item
HPA029641HPA047029SAB3500730
biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

product line

Prestige Antibodies® Powered by Atlas Antibodies

product line

Prestige Antibodies® Powered by Atlas Antibodies

product line

Prestige Antibodies® Powered by Atlas Antibodies

product line

-

Gene Information

human ... TYW5(129450)

Gene Information

human ... TYW3(127253)

Gene Information

human ... TYW1(55253)

Gene Information

human ... TYW1(55253)

Biochem/physiol Actions

In vivo studies using mice models show that sephin1 suppresses neurodegeneration, by preventing eIF2α (eukaryotic initiation factor 2) dephosphorylation.[1]
Sephin1 is a selective inhibitor of a holophosphatase. It is a guanabez derivative that binds to and inhibits a regulatory subunit of the stress-induced protein phosphatase 1 (PPP1R15A), but not the constitutive PPP1R15B, and lacks α2-adrenergic activity. Phosphorylation of eIF2α, α subunit of eukaryotic translation initiation factor 2, reduces protein synthesis and prevents the accumulation of misfolded protein in the endoplasmic reticulum (ER). PPP1R15A recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate eIF2α, so inhibiting PPP1R15A activity prolongs the phosphorylation of eIF2α and aids in its prevention of the accumulation of misfolded protein. In vitro Sephin1 protected cells from lethal protein misfolding and cytotoxic ER stress. In vivo sephin1 prevented two unrelated protein misfolding diseases in mice (Charchot-Marie-Tooth 1B and ALS).
Sephin1 is a selective inhibitor of protein phosphatase 1 (PPP1R15A).

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Skull and crossbones

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML1356-10MG:
SML1356-VAR:
SML1356-BULK:


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PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz.
Crespillo-Casado A, et al.
eLife, 6, e26109-e26109 (2017)
Nadejda Capatina et al.
The Journal of physiology, 599(17), 4153-4181 (2021-07-17)
Endoplasmic reticulum (ER) stress promotes placental dysmorphogenesis and is associated with poor pregnancy outcomes. We show that unfolded protein response signalling pathways located in the ER drive differentiation of mouse trophoblast stem cells into trophoblast subtypes involved in development of

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