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Safety Information

SML1195

Sigma-Aldrich

Palonosetron hydrochloride

≥98% (HPLC)

Synonym(s):

(3aS)-2-[(3S)-Quinuclidin-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride, (3aS)-2-[(3S)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-Benz[de]isoquinolin-1-one hydrochloride (1:1), RS 25259-197

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About This Item

Empirical Formula (Hill Notation):
C19H24N2O · HCl
CAS Number:
135729-62-3
Molecular Weight:
332.87
MDL number:
MFCD00939524
UNSPSC Code:
12352200
PubChem Substance ID:
329825713
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -90 to -110°, c = 0.4 in H2O

storage condition

desiccated
protect from light

color

white to beige

solubility

H2O: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C1N([C@H]2C3CCN(CC3)C2)C[C@]4([H])C5=C1C=CC=C5CCC4.[H]Cl

InChI

1S/C19H24N2O.ClH/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20;/h2,4,6,13,15,17H,1,3,5,7-12H2;1H/t15-,17-;/m1./s1

InChI key

OLDRWYVIKMSFFB-SSPJITILSA-N

Gene Information

human ... HTR3A(3359)

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Biochem/physiol Actions

Palonosetron is a potent and selective 5-HT3 receptor antagonist (Aloxi) used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML1195-BULK:
SML1195-50MG:
SML1195-VAR:
SML1195-10MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Jing Ma et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(12), 13560-13571 (2019-10-02)
So far, a comprehensive animal model that can mimic both the central and peripheral pathophysiological changes of irritable bowel syndrome (IBS) is lacking. Here, we developed a novel IBS rat model combining trinitro-benzene-sulfonic acid (TNBS) and chronic unpredictable mild stress

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