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Key Documents

Safety Information

SML0765

Sigma-Aldrich

SR1555

≥98% (HPLC)

Synonym(s):

1,1,1,3,3,3-Hexafluoro-2-(4′-((1-(acetyl) piperazine) methyl)-[1,1′-biphenyl]-4-yl)propan-2-ol

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About This Item

Empirical Formula (Hill Notation):
C22H22F6N2O2
CAS Number:
1386439-51-5
Molecular Weight:
460.41
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 15 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

SR1555 is a selective RORγ inverse agonist that inhibits the development and function of TH17 cells, a subset of T cells that have been implicated in the pathology of several autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. SR1555 also increases the frequency of T regulatory cells, an effect not seen with previously described RORγ ligands.

Hazard Statements

H413

Precautionary Statements

P273 - P501

Hazard Classifications

Aquatic Chronic 4

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML0765-VAR:
SML0765-BULK:
SML0765-25MG:
SML0765-5MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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M-H Haddadi et al.
Clinical and experimental immunology, 201(2), 205-221 (2020-05-14)
Regulatory T (Treg ) cell therapy is a promising approach for immune tolerance induction in autoimmunity conditions and cell/organ transplantations. Insufficient isolation yields and impurity during downstream processes and Treg instability after adoptive transfer in inflammatory conditions are major limitations

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