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Safety Information

SML0360

Sigma-Aldrich

TAK-715

≥98% (HPLC)

Synonym(s):

N-(4-(2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl)-2-pyridyl)benzamide

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About This Item

Empirical Formula (Hill Notation):
C24H21N3OS
CAS Number:
303162-79-0
Molecular Weight:
399.51
MDL number:
MFCD17012805
UNSPSC Code:
12352200
PubChem Substance ID:
329825362
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

faintly yellow to dark yellow

solubility

DMSO: >15 mg/mL

storage temp.

2-8°C

SMILES string

CCc1nc(-c2cccc(C)c2)c(s1)-c3ccnc(NC(=O)c4ccccc4)c3

InChI

1S/C24H21N3OS/c1-3-21-27-22(18-11-7-8-16(2)14-18)23(29-21)19-12-13-25-20(15-19)26-24(28)17-9-5-4-6-10-17/h4-15H,3H2,1-2H3,(H,25,26,28)

InChI key

HEKAIDKUDLCBRU-UHFFFAOYSA-N

Gene Information

human ... MAPK14(1432)

Biochem/physiol Actions

TAK-715 is a potent p38 inhibitor that also inhibits CKId/e (casein kinase Id/e), known activator of Wnt/β-catenin signaling.

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML0360-5MG:
SML0360-BULK:
SML0360-VAR:
SML0360-25MG:

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Certificates of Analysis (COA)

Lot/Batch Number
052M4622V

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Jonathan Oliva et al.
The Journal of pharmacology and experimental therapeutics, 370(2), 219-230 (2019-06-14)
Facioscapulohumeral muscular dystrophy (FSHD) is characterized by misexpression of the double homeobox 4 (DUX4) developmental transcription factor in mature skeletal muscle, where it is responsible for muscle degeneration. Preventing expression of DUX4 mRNA is a disease-modifying therapeutic strategy with the
Jean-Philippe Coppé et al.
Nature cell biology, 21(6), 778-790 (2019-06-05)
Phosphorylation networks intimately regulate mechanisms of response to therapies. Mapping the phospho-catalytic profile of kinases in cells or tissues remains a challenge. Here, we introduce a practical high-throughput system to measure the enzymatic activity of kinases using biological peptide targets

Articles

MAPKs

The mitogen-activated protein kinase (MAPK) family consists of both stress activated (SAPK) and mitogen-activated (MAPK) protein kinases. They form a network of signal transduction cascades that mediate cellular responses to a diverse range of stimuli, including growth factors, chemical or osmotic stress, irradiation, bacterial infection and proinflammatory cytokines.

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