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Safety Information

SML0121

Sigma-Aldrich

BTZO-1

≥98% (HPLC)

Synonym(s):

2-Pyridin-2-yl-4H-1,3-benzothiazin-4-one

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About This Item

Empirical Formula (Hill Notation):
C13H8N2OS
CAS Number:
99420-15-2
Molecular Weight:
240.28
MDL number:
MFCD19690951
UNSPSC Code:
12352200
PubChem Substance ID:
329825172
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥7 mg/mL

originator

Takeda

storage temp.

2-8°C

SMILES string

O=C1N=C(Sc2ccccc12)c3ccccn3

InChI

1S/C13H8N2OS/c16-12-9-5-1-2-7-11(9)17-13(15-12)10-6-3-4-8-14-10/h1-8H

InChI key

GBAKVEWPYUIGHN-UHFFFAOYSA-N

Application

BTZO-1 may be used in ARE-mediated gene expression studies.

Biochem/physiol Actions

BTZO-1 is a suppressor of cardiomyocyte apoptosis presumably by activation of antioxidant response element (ARE)-mediated gene expression. BTZO-1 binds to the macrophage migration inhibitory factor (MIF) that is required to activate the glutathione S-transferase Ya subunit (GST Ya) gene ARE.
suppressor of cardiomyocyte apoptosis; ligand of macrophage migration inhibitory factor (MIF)

Features and Benefits

This compound was developed by Takeda. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML0121-BULK:
SML0121-VAR:
SML0121-25MG:
SML0121-5MG:

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Certificates of Analysis (COA)

Lot/Batch Number
081M4616V

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