SMB00395

L-Theanine

≥98% (HPLC)

• Synonym(s): N_γ-Ethyl-L-glutamine, L-Glutamic acid γ-(ethylamide), Suntheanine
• Empirical Formula (Hill Notation): C₇H₁₄N₂O₃
• CAS Number: 3081-61-6
• Molecular Weight: 174.20
• EC Number: 221-379-0
• MDL number: MFCD00059653
• UNSPSC Code: 12352209
• PubChem Substance ID: 329824989
• NACRES: NA.25

Properties

• Product Name: L-Theanine, ≥98% (HPLC)
• Quality Level: 200
• Assay: ≥98% (HPLC)
• form: powder
• color: off-white
• mp: 217-218 °C
• application(s): cell analysis
• storage temp.: 2-8°C
• SMILES string: CCNC(=O)CC[C@H](N)C(O)=O
• InChI: 1S/C7H14N2O3/c1-2-9-6(10)4-3-5(8)7(11)12/h5H,2-4,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
• InChI key: DATAGRPVKZEWHA-YFKPBYRVSA-N

Description

General description

L-Theanine is an analog of glutamine and a component of green tea.

Application

• Safety and Efficacy of AlphaWave L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial.: This clinical trial demonstrates that L-theanine supplementation effectively reduces stress and improves cognitive function without adverse effects (Moulin et al., 2024). (Moulin et al., 2024).


• Inhibitory Role of L-theanine, a Structural Analogue of Glutamate, Against GluR5 Kainate Receptor and its Prospective Utility Against Excitotoxicity.: The study examines L-theanine′s potential in protecting against neurotoxicity by inhibiting specific glutamate receptors (Deb and Borah, 2024). (Deb and Borah, 2024).


• L-theanine abates oxidative stress and mitochondrial dysfunction in myocardial ischemia-reperfusion injury by positively regulating the antioxidant response.: This research demonstrates the cardioprotective effects of L-theanine, highlighting its role in reducing oxidative stress and improving mitochondrial function during heart injuries (García-Niño et al., 2024). (García-Niño et al., 2024).

Biochem/physiol Actions

L-Theanine modulates the activity of several antitumor drugs and has been reported to stimulate self-renewal of human embryonic stem cells. L-Theanine binds to AMPA, Kainate, NMDA, and group I mGlu receptors.

Theanine is able to bind to AMPA, kainite, and NMDA glycine receptors in rat cortical neurons but with less affinity than glutamic acid. It has been studied as a glutamate transport inhibitor, preventing glutamate uptake by M5076 ovarian sarcoma-bearing mouse cells and increasing the effect of doxorubicin on tumor growth in M5076 mice.

Other Notes

Theanine is an amino acid analog of glutamine, found in green tea.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H317
• Precautionary Statements: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable