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Key Documents

Safety Information

SCP0122

Sigma-Aldrich

[Des-Tyr22]-Calcitonin salmon

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About This Item

Empirical Formula (Hill Notation):
C136H231N43O46S2
Molecular Weight:
3268.68
UNSPSC Code:
12352209
NACRES:
NA.32

Assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥75%

storage condition

protect from light

storage temp.

−20°C

Amino Acid Sequence

Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2

Application

Calcitonin, a 32 amino acid polypeptide, is involved in the regulation of calcium and phosphorous metabolism often antagonistic to parathyroid hormone (PTH). [Des-Tyr22]-Calcitonin salmon (Des-Tyr22-sCT) is an analogue of calcitonin with decreased in vitro adenylate cyclase activation activity and inhibitory activity for prolactin release from isolated rat pituitary cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SCP0122-1MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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R M Epand et al.
Journal of medicinal chemistry, 31(8), 1595-1598 (1988-08-01)
Salmon calcitonin has an amino acid sequences that would allow it to form an amphipathic helix from approximately residue 9 to residue 22. We have synthesized a number of analogues of this peptide hormone with deletions in the carboxyl terminus

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