Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

Safety Information

SBR00015

Sigma-Aldrich

AEBSF Ready Made Solution

Synonym(s):

4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C8H10FNO2S · HCl
CAS Number:
30827-99-7
Molecular Weight:
239.69
MDL number:
MFCD00132962
UNSPSC Code:
12352202
NACRES:
NA.85

Assay

≥97%

Quality Level

200

form

liquid

storage condition

protect from light

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H

InChI key

WRDABNWSWOHGMS-UHFFFAOYSA-N

Application

This solution is provided at 100 mM in water. The stock solution may be diluted 1:100 for a 1 mM working concentration. Recommended concentrations for use are 0.1-1.0 mM.

Biochem/physiol Actions

AEBSF is a specific irreversible serine protease inhibitor. It inhibits proteases like chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. AEBSF is an excellent alternative to available serine protease inhibitors as it offers superior inhibitory activity and much lower toxicological risk.

Other Notes

The stability of AEBSF decreases rapidly at higher temperatures and at a pH greater than 7.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SBR00015-BULK:
SBR00015-1ML-PW:
SBR00015-1ML:
SBR00015-VAR:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Toru Hosoi et al.
European journal of pharmacology, 554(1), 8-11 (2006-11-18)
Endoplasmic reticulum stress contributes to several diseases such as neurodegenerative disorders and diabetes. In the previous report, we found that phosphatidylinositol 3-kinase (PI3K) down-regulation is important for inducing CHOP expression, an endoplasmic reticulum stress-induced transcription factor. In the present study
G Lunn et al.
Applied biochemistry and biotechnology, 48(2), 57-59 (1994-08-01)
Five enzyme inhibitors (phenylmethylsulfonyl fluoride, 4-amidinophenylmethanesulfonyl fluoride, 4-(2-aminoethyl)benzenesulfonyl fluoride, N alpha-p-tosyl-L-lysine chloromethyl ketone, and N-tosyl-L-phenylalanine chloromethyl ketone) in buffer, DMSO, or stock solutions were completely degraded by adding 1M NaOH and the final reaction mixtures were not mutagenic. The stability

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service