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Key Documents

Safety Information

SAB4702009

Monoclonal Anti-CD73 PE produced in mouse

new

Synonym(s):

CALJA, E5NT, NT5E, NTE, ecto-5´nucleotidase

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About This Item

UNSPSC Code:
12352203

conjugate

phycoerythrin (R-PE) conjugate

Quality Level

100

antibody product type

primary antibodies

clone

AD2, monoclonal

form

buffered aqueous solution

species reactivity

( Non-human primates), human

technique(s)

flow cytometry: suitable

isotype

IgG1κ

UniProt accession no.

P21589

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... NT5E(4907)

General description

CD73 (ecto-5´-nucleotidase) is a 70 kDa glycoprotein anchored to the extracellular leaflet of the plasma membrane by GPI. This ecto-enzyme catalyzes dephosphorylation of AMP to adenosine. CD73 is expressed in various types of cells, such as epithelial, muscle, and endothelial cells, neutrophils, lymphocytes and fibroblasts. Inflammatory mediators support CD73 expression and its enzymatic activity, leading to the release of adenosine, which modulates inflammation through adenosine receptors. CD73 is expressed in a variety of lymphomas and leukemias, including ALL and CLL, whereas immunodeficient patients usually express low levels of this protein.

Specificity

The mouse monoclonal antibody AD2 recognizes CD73, a 70 kDa GPI-anchored 5´-nucleotidase expressed predominantly on the surface of T and B cell subsets, follicular dendritic cells and endothelial cells.

Immunogen

pre-B leukemia cells

Physical form

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preparation Note

Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Storage and Stability

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Other Notes

The antibody solution should be gently mixed before use.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SAB4702009-100TST:

Certificates of Analysis (COA)

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