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Safety Information

SAB4700298

Sigma-Aldrich

Monoclonal Anti-HLA-A2 azide free antibody produced in mouse

clone BB7.2, purified immunoglobulin, buffered aqueous solution

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

BB7.2, monoclonal

form

buffered aqueous solution

species reactivity

human

concentration

1 mg/mL

technique(s)

flow cytometry: suitable
immunoprecipitation (IP): suitable

isotype

IgG2b

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... HLA-A(3105)

General description

Human leukocyte antigen A α-chain (HLA-A2) is encoded by the gene mapped to human chromosome 6p22.1. HLA-A belongs to the class I molecules of HLa family. The protein structure consists of two polypeptide chains, heavy chain and the non-covalently attached light chain.
The antibody BB7.2 recognizes an epitope at the C-terminus of alpha-2 helix and a turn on one of the underlying beta strands within the human HLA-A2 histocompatibility antigen.

The previously assigned protein identifier P01891 has been merged into P04439. Full details can be found on the UniProt database.

Immunogen

HLA-A2 solubilized by papain

Application

The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 5-10 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Biochem/physiol Actions

Human leukocyte antigen A α-chain (HLA-A2) plays a major role in peptide antigen presentation. The encoded protein interacts with cytotoxic T cells (CTL) and facilitates the identification of peptide derived from the influenza matrix protein.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in azide free phosphate buffered saline, pH 7.4; 0.2 um filter sterilized.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SAB4700298-100UG:


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cytotoxic T lymphocytes recognize a fragment of influenza virus matrix protein in association with HLA-A2
Gotch F
Nature, 326, 881-882 (1987)
Structure of the human class I histocompatibility antigen, HLA-A2.
Bjorkman PJ
Nature, 329, 506-512 (1987)
Modern vitiligo genetics sheds new light on an ancient disease
Spritz RA
The Journal of Dermatology, 40, 310-318 (2013)

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