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Key Documents

Safety Information

SAB4503821

Sigma-Aldrich

Anti-phospho-HSL (pSer855/554) antibody produced in rabbit

affinity isolated antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 116 kDa

species reactivity

mouse, rat, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

Q05469

UniProt accession no.

Q05469

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer855/pSer554)

Gene Information

human ... LIPE(3991)

General description

Hormone sensitive lipase (HSL) is coded by LIPE (lipase E) gene. The gene coding for a protein is mapped on human chromosome 19q13. The encoded protein is an intracellular lipase with various neutral lipid substrates, such as triglycerides, diglycerides, monoglycerides, cholesterol esters and retinyl esters. HSL is widely expressed.

Immunogen

The antiserum was produced against synthesized peptide derived from human HSL around the phosphorylation site of Ser855/554.

Immunogen Range: 520-569

Biochem/physiol Actions

Hormone sensitive lipase (HSL) plays an important role in various processes such as lipolysis, adipocytes, steroidogenesis and spermatogenesis. Deficiency of HSL contributes to histologic abnormalities in white adipose tissue and an increase in macrophage infiltration. Polymorphism in the gene has been observed in familial lipodystrophies patients.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SAB4503821-100UG:

Certificates of Analysis (COA)

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Identification of Microdeletions Spanning the Diamond-Blackfan Anemia Locus on 19q13 and Evidence for Genetic Heterogeneity
Gustavsson P, et al.
American Journal of Human Genetics, 63, 1388-1395 (1998)
A novel LIPE nonsense mutation found using exome sequencing in siblings with late-onset familial partial lipodystrophy.
Farhan SM, et al.
The Canadian Journal of Cardiology, 30, 1649-1654 (2014)
Null Mutation in Hormone-Sensitive Lipase Gene and Risk of Type 2 Diabetes
Albert JS, et al.
The New England Journal of Medicine, 370, 2307-2315 (2014)
Toshiya Okumura et al.
PloS one, 9(6), e100559-e100559 (2014-06-20)
Phosphorylation of hormone-sensitive lipase (HSL) and perilipin by protein kinase A (PKA) promotes the hydrolysis of lipids in adipocytes. Although activation of lipolysis by PKA has been well studied, inactivation via protein phosphatases is poorly understood. Here, we investigated whether

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