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Safety Information

SAB4200870

Sigma-Aldrich

Anti-Akkermancia muciniphila antibody produced in rabbit

IgG fraction of antiserum

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

form

liquid

species reactivity

(Akkermancia muciniphila)

packaging

pkg of 100 μL
pkg of 25 μL

concentration

~1 mg/mL

technique(s)

immunoblotting: 1:500-1:1000 using Akkermansia muciniphila lysate

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

General description

Akkermansia muciniphila is a Gram negative, oval shaped, non-motile, non-spore forming strictly anaerobic bacteria.1 A. muciniphila colonized in the mucus layer of the human intestine niche. A muciniphila inhabits the gastrointestinal tracts of most of healthy adults and represents 1-4% of the total fecal microbiota starting from early life.2 It is one of the top 20 most abundant species detectable in the human gut.3 It was found that A. muciniphila abundance in the gut was correlated to a healthy intestine and inversely correlated to many disease conditions.2 In comparison to healthy controls, A. muciniphila levels were low in intestinal disorders, such inflammatory bowel disease IBD, but also in other conditions, such as autism, atopy, and obesity.2,5-8 Therefore, A. muciniphila was suggested to serve as a marker of healthy intestine.
In addition, goring research identified A. muciniphila as a promising potential probiotic that can be administrated for the treatment of diseases such as, colitis, metabolic syndromes, immune diseases and cancer. However more research is needed to verify the safety of oral administration of A. muciniphila in humans.3

Specificity

Anti-Akkermansia muciniphila antibody recognizes A. muciniphila lysate and whole dead bacteria.

Biochem/physiol Actions

A. muciniphila is able to degrade mucin, a key mucus component, using the enzymes sialidase and fucosidase, and utilize it as a source of carbon and nitrogen.2 Mucin degradation by A. muciniphila results in the production of short-chain fatty acids (SCFA), that become available metabolites to the host and also can stimulate the host immune system. Moreover, SCFA promotes the growth and metabolic activity of mucus- associated gut microbiota preventing the pathogenic bacteria from reaching the intestinal cells.4

Physical form

Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.

Storage and Stability

For continuous use, store at 2-8°C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog  our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SAB4200870-100UL:
SAB4200870-VAR:
SAB4200870-BULK:
SAB4200870-25UL:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ting Zhang et al.
Microbial biotechnology, 12(6), 1109-1125 (2019-04-23)
Akkermansia muciniphila (A. muciniphila), an intestinal symbiont colonizing in the mucosal layer, is considered to be a promising candidate as probiotics. A. muciniphila is known to have an important value in improving the host metabolic functions and immune responses. Moreover, A. muciniphila may
A Santacruz et al.
The British journal of nutrition, 104(1), 83-92 (2010-03-09)
Obesity is associated with complications during pregnancy and increased health risks in the newborn. The objective of the present study was to establish possible relationships between gut microbiota, body weight, weight gain and biochemical parameters in pregnant women. Fifty pregnant
Muriel Derrien et al.
International journal of systematic and evolutionary microbiology, 54(Pt 5), 1469-1476 (2004-09-25)
The diversity of mucin-degrading bacteria in the human intestine was investigated by combining culture and 16S rRNA-dependent approaches. A dominant bacterium, strain MucT, was isolated by dilution to extinction of faeces in anaerobic medium containing gastric mucin as the sole

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