S8688

SR 59230A

≥98% (HPLC), powder, β3-Adrenoceptor antagonist

• Synonym(s): 3-(2-Ethylphenoxy)-1-[[(1S)-1,2,3,4-tetrahydronaphth-1-yl]amino]-(2S)-2-propanol oxalate salt
• Empirical Formula (Hill Notation): C₂₁H₂₇NO₂ · C₂H₂O₄
• CAS Number: 174689-39-5
• Molecular Weight: 415.48
• MDL number: MFCD00940163
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278715
• NACRES: NA.77

Properties

• product name: SR 59230A, ≥98% (HPLC), powder
• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white
• solubility: DMSO: >10 mg/mL; H₂O: insoluble
• originator: Sanofi Aventis
• SMILES string: OC(=O)C(O)=O.CCc1ccccc1OC[C@@H](O)CN[C@H]2CCCc3ccccc23
• InChI: 1S/C21H27NO2.C2H2O4/c1-2-16-8-4-6-13-21(16)24-15-18(23)14-22-20-12-7-10-17-9-3-5-11-19(17)20;3-1(4)2(5)6/h3-6,8-9,11,13,18,20,22-23H,2,7,10,12,14-15H2,1H3;(H,3,4)(H,5,6)/t18-,20-;/m0./s1
• InChI key: XTBQNQMNFXNGLR-MKSBGGEFSA-N
• Gene Information: human ... ADRB3(155)

Description

Application

SR 59230A was used in the identification of β-adrenoceptors in rat aorta.³ It was tested as a potential therapeutic agent in improving cardiac function in rat model of heart failure.⁴

Biochem/physiol Actions

SR 59230A is a β3-adrenoceptor antagonist. It has high affinity for the β3 adrenoceptors occurring in human gut that affect the function of human colonic circular smooth muscle.¹ It is reported that SR 59230A inhibits the Kir2.1-2.3 cardiac potassium channels.²

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves