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Safety Information

S1437

Sigma-Aldrich

Sex Hormone-Binding Globulin from human serum

≥95% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

SHBG, Testosterone-estradiol binding globulin

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About This Item

MDL number:
MFCD00163748
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human serum

Quality Level

200

Assay

≥95% (SDS-PAGE)

form

buffered aqueous glycerol solution

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

P04278

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... SHBG(6462)

General description

Sex hormone binding globulin (SHBG) is secreted by the liver. It is also expressed in the endometrium, ovary and testis. SHBG is composed of 402 amino acids and the gene encoding it is localized on human chromosome 17p12–p13.

Application

Sex hormone binding globulin (SHBG) from human serum has been used as a spiked sample in radioimmunoassay. It may also be used to study the effects of hydroxylated estrogen metabolites (2-OH-E2 and 4-OH-E2) on the mRNA and protein expression of SHBG in MCF-7 human breast cancer cell line.

Biochem/physiol Actions

Sex hormone binding globulin (SHBG) is a dimeric plasma glycoprotein with high affinity for the gonadal steroids, testosterone and estradiol. It regulates the availability of sex steroid hormones and limits their access to target cells. SHBG also inhibits estradiol-induced proliferation of breast cancer cells. Alterations in the expression of the protein have been linked to male infertility.

Physical form

Solution in 20 mM Tris-HCl, 10% Glycerol, pH 7.4

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

S1437-10UG-PW:
S1437-VAR:
S1437-10UG:
S1437-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
SLCL5767
SLCG6392
SLCD0584
SLBT4785
SLBS0677V

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Developmental time course of estradiol, testosterone, and dihydrotestosterone levels in discrete regions of male and female rat brain
Konkle ATM and McCarthy MM
Endocrinology, 152(1), 223-235 (2011)
Correlation between SHBG gene polymorphism and male infertility in Han population of Henan province of China
A STROBE-compliant article
Yuan-rong Cui
Medicine (2017)
Sex Hormone-Binding Globulin (SHBG), estradiol and breast cancer.
Fortunati N
Molecular and Cellular Endocrinology (2010)
The ability of hydroxylated estrogens (2-OH-E2 and 4-OH-E2) to increase
of SHBG gene, protein expression and intracellular levels in MCF-7 cells
line
Gregoraszczuk EL
Endocrine regulations (2011)

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