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Safety Information

S0520

Sigma-Aldrich

Selenocystamine dihydrochloride

>98% (TLC), suitable for ligand binding assays

Synonym(s):

2,2′-diselenobis-Ethanamine hydrochloride (1:2)

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About This Item

Empirical Formula (Hill Notation):
C4H12N2Se2 · 2HCl
CAS Number:
3542-13-0
Molecular Weight:
318.99
MDL number:
MFCD00035445
UNSPSC Code:
12352116
PubChem Substance ID:
24899440
NACRES:
NA.26

product name

Selenocystamine dihydrochloride, powder

Assay

>98% (TLC)

Quality Level

200

form

powder

technique(s)

ligand binding assay: suitable

color

yellow to orange

solubility

H2O: soluble, clear to slightly hazy

SMILES string

NCC[Se][Se]CCN.[H]Cl.[H]Cl

InChI

1S/C4H12N2Se2.ClH/c5-1-3-7-8-4-2-6;/h1-6H2;1H

InChI key

PKRYDZYGNSZBHO-UHFFFAOYSA-N

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General description

Selenocystamine dihydrochloride has a potential to block the activity of influenza A and B virus associated RNA-dependent RNA polymerase enzyme.

Application

Selenocystamine dihydrochloride has been used to determine its effect on PP2A phosphatase activity in vitro. It has also been used as a catalyst for a disulfide-cleaving reagent, dithiothreitol (DTT).

Signal Word

Danger

Hazard Statements

H301 + H331,H373,H410

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Poisonous substance

PRTR

Class I Designated Chemical Substances

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

S0520-100MG:4548173209722
S0520-1G:4548173281261
S0520-VAR:
S0520-BULK:
S0520-250MG:4548173281278
S0520-25MG:4548173209739

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sodium selenate specifically activates PP2A phosphatase, dephosphorylates tau and reverses memory deficits in an Alzheimer?s disease model
Corcoran NM, et al.
Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, 17(8), 1025-1033 (2010)
Conquest of viral diseases: a topical review of drugs and vaccines, 1 (1985)
Di Ding et al.
Biochemical and biophysical research communications, 361(3), 629-633 (2007-08-04)
Two distinct stereospecific methionine sulfoxide reductases (Msr), MsrA and MsrB reduce the oxidized methionine (Met), methionine sulfoxide [Met(O)], back to Met. In this report, we examined the reducing systems required for the activities of two chloroplastic MsrB enzymes (NtMsrB1 and
Y Hou et al.
Biochemical and biophysical research communications, 228(1), 88-93 (1996-11-01)
Seleno compounds such as selenocystamine and seleno-D, L-cystine were found to catalyze the decomposition of S-nitrosothiols (e.g. S-nitroso-glutathione and S-nitroso-N-acetyl-D, L-penicillamine) in the presence of different thiols (e.g. glutathione, N-acetyl-D-penicillamine and 2-mercaptoethanol), and liberate nitric oxide. It was also found
Transferrin serves as a mediator to deliver organometallic ruthenium (II) anticancer complexes into cells
Guo W, et al.
Inorganic Chemistry, 52(9), 5328-5338 (2013)
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