R7382

Rifampicin

suitable for plant cell culture, BioReagent, ≥97% (HPLC), crystalline

• Synonym(s): 3-(4-Methylpiperazinyliminomethyl)rifamycin SV, Rifampin, Rifamycin AMP
• Empirical Formula (Hill Notation): C₄₃H₅₈N₄O₁₂
• CAS Number: 13292-46-1
• Molecular Weight: 822.94
• Beilstein: 5723476
• EC Number: 236-312-0
• MDL number: MFCD00151389
• PubChem Substance ID: 24899391
• NACRES: NA.72

Properties

• product line: BioReagent
• Quality Level: 200
• Assay: ≥97% (HPLC)
• form: crystalline
• technique(s): cell culture | plant: suitable
• solubility: chloroform: 50 mg/mL, clear
• antibiotic activity spectrum: Gram-negative bacteria; Gram-positive bacteria; mycobacteria
• application(s): agriculture
• Mode of action: protein synthesis | interferes
• storage temp.: −20°C
• SMILES string: CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(NC(=O)C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(\C=N\N5CCN(C)CC5)c(O)c4c3C2=O
• InChI: 1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1
• InChI key: JQXXHWHPUNPDRT-WLSIYKJHSA-N

Description

General description

Chemical structure: macrolide

Application

Rifampicin, a rifamycin, is active against mycobacteria. Rifamycin, is also an inhibitor of chloroplast RNA polymerase and may be used to study chloroplast-level DNA transcription in plants.

Biochem/physiol Actions

Inhibits the assembly of DNA and protein into mature virus particles.

Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Product is sensitive to light and moisture. Store under inert gas.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves