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Safety Information

PZ0354

Sigma-Aldrich

PF-04363467 hydrochloride

≥98% (HPLC)

Synonym(s):

(S)-N-[4-(4-Ethyl-2-morpholinyl)-2-methylphenyl]-4-(1-methylethyl)benzenesulfonamide hydrochloride, N-[4-[(2S)-4-Ethyl-2-morpholinyl]-2-methylphenyl]-4-(1-methylethyl)-benzenesulfonamide hydrochloride, PF-4363467 hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C22H30N2O3S · HCl
CAS Number:
2040055-81-8
Molecular Weight:
439.01
UNSPSC Code:
51111800
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 3 mg/mL, clear (warmed)

storage temp.

room temp

SMILES string

[H]Cl.CC1=CC([C@H]2CN(CC)CCO2)=CC=C1NS(C3=CC=C(C(C)C)C=C3)(=O)=O

Biochem/physiol Actions

PF-4363467 hydrochloride is a Dopamine D3/D2 receptor antagonist. PF-4363467 has 100-fold selectivity for D3 with a Ki value of 3.1 nM for D3R compared to a Ki value of 692 nM for D2R and high selectivity for D3R compared to other biogenic amine receptors. PF-4363467 attenuated opioid drug-seeking behavior in a rat model of addiction without causing the extrapyramidal symptoms often associated with D2R antagonism.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

PZ0354-5MG:
PZ0354-VAR:
PZ0354-25MG:
PZ0354-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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