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Safety Information

PZ0274

Sigma-Aldrich

PF-01247324

≥98% (HPLC)

Synonym(s):

6-Amino-5-(2,3,5-trichlorophenyl)pyridine-2-carboxylic acid methylamide, 6-Amino-N-methyl-5-(2,3,5-trichlorophenyl)-2-Pyridinecarboxamide, N-Methyl-6-amino-5-(2,3,5-trichlorophenyl)pyridine-2-carboxamide, PF 01247324, PF-1247324

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About This Item

Empirical Formula (Hill Notation):
C13H10Cl3N3O
CAS Number:
875051-72-2
Molecular Weight:
330.60
UNSPSC Code:
41121801
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

room temp

InChI

1S/C13H10Cl3N3O/c1-18-13(20)10-3-2-7(12(17)19-10)8-4-6(14)5-9(15)11(8)16/h2-5H,1H3,(H2,17,19)(H,18,20)

InChI key

HPIUHDCRVYDAEJ-UHFFFAOYSA-N

Biochem/physiol Actions

In humans, PF-01247324 [6-amino-5-(2, 3, 5-trichloro-phenyl)-pyridine-2-carboxylic acid methylamide] prevents native tetrodotoxin-resistant (TTX-R) currents in dorsal root ganglion (DRG) neurons.
PF-01247324 is an orally bioavailable, selective and potent NaV1.8 channel blocker that inhibits that exhibits analgesic efficacy in rodent behavioral models of pain.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301,H315,H319,H335

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

PZ0274-25MG:
PZ0274-VAR:
PZ0274-BULK:
PZ0274-5MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sigma-Aldrich

SML1061

PF-04856264

A novel selective and orally bioavailable Nav1. 8 channel blocker, PF?01247324, attenuates nociception and sensory neuron excitability.
Payne CE, et al.
British Journal of Pharmacology, 172(10), 2654-2670 (2015)

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