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Key Documents

Safety Information

PRS3335

Sigma-Aldrich

Anti-Bcl-2 (ab1) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-B-cell CLL/lymphoma 2

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About This Item

MDL number:
MFCD00239644
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, mouse

technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

P10415

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... BCL2(596)

Related Categories

General description

B-cell lymphoma 2 (BCL2), a proto-oncogene is made of three exons. It is widely expressed in immature B-cells and memory B cells. BCL2 is found at high levels in the thymus, spleen, and lymph nodes. BCL2 gene is mapped to human chromosome 18q21.33.

Immunogen

a peptide corresponding to 15 amino acids near the N-terminus of human Bcl-2.

Application

Anti-Bcl-2 (ab1) antibody produced in rabbit has been used in western blotting (1:100) (1:1000), immunohistochemistry (1:50), immunoprecipitation (IP) (1:1000)

Biochem/physiol Actions

B-cell lymphoma 2 (BCL2) plays a key role in maintaining the integrity of the mitochondrial membrane. It blocks the release of cytochrome C and its binding to apoptosis activating factor-1 (APAF1). BCL2 family proteins participate in modulating cell death. It also regulates apoptosis, necrosis, and autophagy. Upregulation of BCL2 is seen in several human cancers. Overexpression of BCL2 is observed in chronic lymphocytic leukemia (CLL), marginal cell lymphoma, and mantle cell lymphoma.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3335.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

PRS3335-100UG:

Certificates of Analysis (COA)

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