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Safety Information

P3360

Sigma-Aldrich

Prostate Specific Antigen–α1-Antichymotrypsin Complex human

≥99% (SDS-PAGE), buffered aqueous solution

Synonym(s):

PSA-ACT

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About This Item

CAS Number:
141176-92-3
MDL number:
MFCD00286324
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

Quality Level

200

Assay

≥99% (SDS-PAGE)

form

buffered aqueous solution

UniProt accession no.

P01011
P07288

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... KLK3(354) , SERPINA3(12)

General description

Kallikrein-3 (KLK3) or prostate specific antigen (PSA) is a serine protease. The protein contains a 371-residue N-terminal heavy chain, which is composed of four Apple domains. The PSA gene is localized to human chromosome 4q35. PSA is synthesized in the liver as a proenzyme known as prekallikrein. It is a key component of the kinin-generating pathways (PK system). The protein is involved in important physiological roles, such as blood pressure modulation, complement activation, and control and maintenance of inflammatory responses. KLK3b alleles are found to be associated with end-stage renal disease (ESRD) suggesting that variants in KLK3 gene might be linked with ESRD susceptibility.
SERPINA3 is also known as α-1-antichymotrypsin (ACT or AACT). The gene consists of five exons and is mapped to human chromosome 14q32.13. The protein contains 423 amino acids and belongs to the family of serpin superfamily of protease inhibitors. SERPINA3 inhibits the activity of pancreatic chymotrypsin, leukocyte, cathepsin G, mast cell chymases, human glandular, kallikrein 2 and kallikrein 3. Elevated expression of the protein has been observed in various types of carcinomas including breast carcinoma, hepatocellular carcinoma, prostate carcinoma and adenocarcinoma of the lung.

Other Notes

PSA from Human seminal fluid; Antichymotrypsin from human plasma

Physical form

Solution in 10 mM Sodium Acetate pH 5.6, 150 mM sodium chloride and 0.1% sodium azide.

Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

P3360-10UG-PW:
P3360-VAR:
P3360-10UG:
P3360-BULK:

Certificates of Analysis (COA)

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SERPINA3 promotes endometrial cancer cells growth by regulating G2/M cell cycle checkpoint and apoptosis.
International Journal of Clinical and Experimental Pathology (2014)
Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein.
Tang J
The Journal of Biological Chemistry, 280(49) (2005)
Down-regulated expression of SERPIN genes located on chromosome 18q21 in oral squamous cell carcinomas.
Shiiba M
Oncology Reports, 24(1) (2010)
Identification of human plasma kallikrein gene polymorphisms and evaluation of their role in end-stage renal disease.
Yu H
Hypertension, 31(4) (1998)
SERPINA3 (aka alpha-1-antichymotrypsin).
Baker C
Frontiers in Bioscience (2007)
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