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Safety Information

P2533

Sigma-Aldrich

Poly-L-ornithine hydrochloride

suitable for ligand binding assays, Mol wt 15,000-30,000

Synonym(s):

L-Ornithine homopolymer hydrochloride

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About This Item

CAS Number:
26982-21-8
MDL number:
MFCD00166412
UNSPSC Code:
12352209
PubChem Substance ID:
24898334
NACRES:
NA.26

product name

Poly-L-ornithine hydrochloride, mol wt 15,000-30,000

form

powder or solid

mol wt

15,000-30,000

technique(s)

ligand binding assay: suitable

color

white to off-white

storage temp.

−20°C

SMILES string

Cl.NCCCC(N)C(O)=O

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Application

Poly-L-ornithine hydrochloride has been used as a substrate analog of acetyl-poly-L-lysine to study substrate binding and catalysis of the NAD-dependent protein deacetylase Hst2. It has been used to bind alginate-polycation-alginate (APA) microcapsules.

Biochem/physiol Actions

Poly-L-ornithine is a polycationic synthetic amino acid polymer. It boosts nasal absorption of hydrophilic macromolecular drugs. Poly-L-ornithine is a specialized coating that acts as a charge modifier.

Analysis Note

Molecular weight based on viscosity.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

P2533-50MG:
P2533-BULK:
P2533-10MG:
P2533-1G:
P2533-500MG:
P2533-100MG:
P2533-VAR:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Adriana Di Polo, Leonard A. Levin
Ocular Neuroprotection (2003)
Kun Luo et al.
Journal of integrative neuroscience, 20(3), 529-539 (2021-10-15)
Rab3a, a subtype protein in the Rab3 family amongst the small G proteins, is closely associated with the learning and memory formation process. Various neuronal stimuli can induce the expression of Rab3a; however, how DNA modification is involved in regulating
Hierarchical Structure Formation of Cylindrical Brush Polymer?Surfactant Complexes
Cong, Y. et al.
Langmuir, 25, 6392-6397 (2005)
Emmanuel C. Opara
Methods in Molecular Biology (2017)
Preparation and Evaluation of PEGylated Poly-L-ornithine Complex as a Novel Absorption Enhancer
Yusuke K
Biologicals : Journal of the International Association of Biological Standardization (2017)
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Articles

Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.

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