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P0430

Sigma-Aldrich

Periodic acid

suitable for electrophoresis, ≥99%

Synonym(s):

Iodic acid, Orthoperiodic acid, Paraperiodic acid

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About This Item

Empirical Formula (Hill Notation):
H5IO6
CAS Number:
10450-60-9
Molecular Weight:
227.94
EC Number:
233-937-0
MDL number:
MFCD00011344
UNSPSC Code:
41105319
PubChem Substance ID:
24898104
NACRES:
NB.22

Assay

≥99%

form

powder or crystals

reaction suitability

reagent type: oxidant

technique(s)

electrophoresis: suitable

mp

122 °C (lit.)

solubility

water: 100 mg/mL, clear, colorless

SMILES string

OI(O)(O)(O)(O)=O

InChI

1S/H5IO6/c2-1(3,4,5,6)7/h(H5,2,3,4,5,6,7)

InChI key

TWLXDPFBEPBAQB-UHFFFAOYSA-N

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Application

Periodic acid is commonly used as a component for glycoprotein stains. Selective staining of glycoproteins on SDS-PAGE and membranes is carried out using a modification of the Periodic Acid-Schiff (PAS) method. Staining of sugar moieties of glycoproteins yields magenta bands with a colorless background. The Periodic Acid/Schiff Reagent stains vicinal diol groups found mainly on peripheral sugars and sialic acids and is used as a general glycoprotein stain. Periodic acid is also used to cleave reversible cross-linkers (e.g. DATD, DHEBA) in PAGE gels.

Analysis Note

Tested for use in staining of glycoproteins.

Signal Word

Danger

Hazard Statements

H271,H314,H372,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Ox. Sol. 1 - Skin Corr. 1B - STOT RE 1 Oral

Target Organs

Thyroid

Storage Class Code

5.1A - Strongly oxidizing hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 1: Oxidizing solids
Periodic acid
Hazardous rank I
1st oxidizing solid

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

P0430-100G:4548173991276
P0430-25G:4548173991283
P0430-BULK:
P0430-VAR:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Glycoprotein staining following electrophoresis on acrylamide gels.
R M Zacharius et al.
Analytical biochemistry, 30(1), 148-152 (1969-07-01)
Identification of glycoproteins on nitrocellulose membranes and gels.
D J Thornton et al.
Methods in molecular biology (Clifton, N.J.), 32, 119-128 (1994-01-01)
Courtney M Anderson et al.
Skeletal muscle, 5, 7-7 (2015-03-20)
Skeletal muscle is the most abundant tissue in the body and is a major source of total energy expenditure in mammals. Skeletal muscle consists of fast and slow fiber types, which differ in their energy usage, contractile speed, and force
Murad Alturkustani et al.
Journal of neuropathology and experimental neurology, 74(3), 233-240 (2015-02-11)
The pathologic features of adult-onset leukoencephalopathy/leukodystrophy with axonal spheroids (ALAS) are variable, and this has led to different hypotheses as to whether primarily demyelination or axonopathy may underlie this disorder. Typical ALAS pathology is rarely accompanied by focal multiple sclerosis
Aranzazu Villasante et al.
Biomaterials, 35(22), 5785-5794 (2014-04-22)
Monolayer cultures of tumor cells and animal studies have tremendously advanced our understanding of cancer biology. However, we often lack animal models for human tumors, and cultured lines of human cells quickly lose their cancer signatures. In recent years, simple
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Articles

NMR Analysis of Glycans

Nuclear magnetic resonance (NMR) spectroscopy measures the extent to which a glycan or other molecule distorts a magnetic field.

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