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Safety Information

P0393

Sigma-Aldrich

Protein Kinase Inhibitor from porcine heart

1-3 inhibitor U/μg protein, lyophilized powder

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About This Item

MDL number:
MFCD00132115
UNSPSC Code:
12352202

biological source

Porcine heart

form

lyophilized powder

specific activity

1-3 inhibitor U/μg protein

composition

Protein, ~50% biuret

storage temp.

2-8°C

Biochem/physiol Actions

These proteins bind to the catalytic subunit of cyclic-AMP dependent protein kinase, displacing the regulatory subunit and inhibiting phosphorylating activity. The cyclic-AMP binding capacity of the regulatory subunit is enhanced. Many other proteins exhibit this enhancement ability, too (Brostrom, C.O. and Kon, C., Anal. Biochem., 58, 459 [1974]).

Packaging

Package size based on protein content.

Unit Definition

One unit will transfer 1.0 picomole (10-12 mol) of phosphate from γ-32P-ATP to hydrolyzed and partially dephosphorylated casein (Product No. C 4765) per min at pH 6.5 at 30 °C.

Physical form

Supplied as lyophilized powder containing 30% glycerophosphate and 20% EDTA.

Preparation Note

Fractionated essentially by procedure of Walsh, D.A., et al., J. Biol. Chem., 246, 1977 (1971).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

P0393-5MG:
P0393-VAR:
P0393-BULK:
P0393-1MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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