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N7389

Sigma-Aldrich

3-Nitro-L-tyrosine

crystalline

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About This Item

Linear Formula:
O2NC6H3-4-(OH)CH2CH(NH2)CO2H
CAS Number:
621-44-3
Molecular Weight:
226.19
Beilstein:
2813157
EC Number:
210-688-6
MDL number:
MFCD00007123
UNSPSC Code:
12352200
eCl@ss:
32160406
PubChem Substance ID:
24897825
NACRES:
NA.32

form

crystalline

Quality Level

200

mp

233-235 °C (dec.) (lit.)

SMILES string

N[C@@H](Cc1ccc(O)c(c1)[N+]([O-])=O)C(O)=O

InChI

1S/C9H10N2O5/c10-6(9(13)14)3-5-1-2-8(12)7(4-5)11(15)16/h1-2,4,6,12H,3,10H2,(H,13,14)/t6-/m0/s1

InChI key

FBTSQILOGYXGMD-LURJTMIESA-N

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Application

3-Nitro-L-tyrosine has been used in:
  • western blot analysis to quantify the nitrotyrosine levels in mice tissue protein
  • Murashige–Skoog medium to treat wild type and mitogen-activated protein kinase 6 (mpk6)-2 mutant seedlings for inferring the connection between nitric oxide (NO) and MPK6 functions in the regulation of mitotic microtubule organization
  • immunocytochemistry

Biochem/physiol Actions

3-Nitro-L-tyrosine is an oxidant and cytotoxic agent. 3-Nitrotyrosine serves as a biological marker of proteins modified by nitrogen-free radical species in systemic autoimmunogenic conditions. It is a marker for oxidative damage mediated by peroxynitrite. Nitrotyrosine is associated with VEGF-C expression and lymph node metastasis in breast cancer. 3-Nitrotyrosine is produced due to oxidative/nitrosative stress-mediated chemical modifications such as nitration of proteins, which is observed in lung carcinogenesis.

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Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

N7389-BULK:
N7389-5G:
N7389-25G:
N7389-10G:
N7389-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCD7454
BCBZ9143
BCBZ7574
BCBW0864
BCBT2005

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