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Safety Information

N2540

Sigma-Aldrich

NS5806

≥98% (HPLC)

Synonym(s):

N-[3,5-bis(trifluoromethyl)phenyl]-N′-[2,4-dibromo-6-(1H-tetrazol-5-yl)phenyl]-urea

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About This Item

Empirical Formula (Hill Notation):
C16H8Br2F6N6O
CAS Number:
426834-69-7
Molecular Weight:
574.07
MDL number:
MFCD18432708
UNSPSC Code:
12352200
PubChem Substance ID:
329818416
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to faint yellow

solubility

DMSO: >30 mg/mL

storage temp.

2-8°C

SMILES string

FC(F)(F)c1cc(NC(=O)Nc2c(Br)cc(Br)cc2-c3nnn[nH]3)cc(c1)C(F)(F)F

InChI

1S/C16H8Br2F6N6O/c17-8-4-10(13-27-29-30-28-13)12(11(18)5-8)26-14(31)25-9-2-6(15(19,20)21)1-7(3-9)16(22,23)24/h1-5H,(H2,25,26,31)(H,27,28,29,30)

InChI key

UZWJWROOLOOCPQ-UHFFFAOYSA-N

Biochem/physiol Actions

NS5806 increases peak current amplitude of the potassium channel Kv4.3 (EC50 = 5.3 uM). NS5806 also slows Kv4.3 and Kv4.2 current dacay in channel complexes containing KChIP2. In ventricular cardiomycytes, NS5806 increases transient outward current and reproduces the electrocardiographic profile of Brugada syndrome.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301,H413

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 4

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

N2540-VAR:
N2540-5MG:
N2540-25MG:
N2540-BULK:
N2540-IP:

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Certificates of Analysis (COA)

Lot/Batch Number
027M4609V
110M4610V

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Jinjing Yao et al.
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