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Safety Information

M6145

Sigma-Aldrich

1-Thioglycerol

liquid, BioReagent, suitable for cell culture, ≥97% (titration)

Synonym(s):

α-Monothioglycerol, α-Thioglycerol, 3-Mercapto-1,2-propanediol

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About This Item

Linear Formula:
HSCH2CH(OH)CH2OH
CAS Number:
96-27-5
Molecular Weight:
108.16
Beilstein:
1732046
EC Number:
202-495-0
MDL number:
MFCD00004879
UNSPSC Code:
12352211
PubChem Substance ID:
24897080
NACRES:
NA.75

biological source

synthetic (organic)

Quality Level

200

product line

BioReagent

Assay

≥97% (titration)

form

liquid

technique(s)

cell culture | mammalian: suitable
single cell analysis: suitable

refractive index

n20/D 1.527 (lit.)

bp

118 °C/5 mmHg (lit.)

solubility

water: miscible 0.1 M

density

1.25 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

OCC(O)CS

InChI

1S/C3H8O2S/c4-1-3(5)2-6/h3-6H,1-2H2

InChI key

PJUIMOJAAPLTRJ-UHFFFAOYSA-N

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Application

Cell culture studies of embryonic cortical and hippocampal neurons, mouse bone marrow mast cell lines, and human Β cell lines have utilized 1-thioglycerol as a component of the culture medium to stimulate proliferation.

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Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Skin Irrit. 2 - Skin Sens. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

210.2 °F - closed cup

Flash Point(C)

99 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Type 3 petroleums
Hazardous rank III
Water insoluble liquid

JAN Code

M6145-25ML:
M6145-500ML:
M6145-VAR:
M6145-BULK:
M6145-250ML:
M6145-100ML:
M6145-50ML:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Suji Lee et al.
Stem cells (Dayton, Ohio), 36(10), 1552-1566 (2018-07-14)
Although autologous induced pluripotent stem cells (iPSCs) can potentially be useful for treating patients without immune rejection, in reality it will be extremely expensive and labor-intensive to make iPSCs to realize personalized medicine. An alternative approach is to make use
Carissa Dege et al.
Developmental cell, 53(2), 229-239 (2020-03-21)
Natural killer (NK) cells are a critical component of the innate immune system. However, their ontogenic origin has remained unclear. Here, we report that NK cell potential first arises from Hoxaneg/low Kit+CD41+CD16/32+ hematopoietic-stem-cell (HSC)-independent erythro-myeloid progenitors (EMPs) present in the
Cheryl Stork et al.
Nucleic acids research, 47(3), 1532-1543 (2018-11-30)
X-inactive-specific transcript (Xist) is a long noncoding RNA (lncRNA) essential for inactivating one of the two X chromosomes in mammalian females. Random X chromosome inactivation is mediated by Xist RNA expressed from the inactive X chromosome. We found that Xist
P Tengvall et al.
Biomaterials, 17(10), 1001-1007 (1996-05-01)
Thiol-modified surfaces are chemically well defined and suited for surface biological model experiments and biomaterials research. 3-Mercapto-1,2-propanediol (mercaptoglycerol, MG), immobilized on gold, spontaneously binds immunoglobulins from human serum and activates the complement system. The surface-bound complement factors were detected by
Valérie Gagnard et al.
Bioorganic & medicinal chemistry, 12(6), 1393-1402 (2004-03-17)
A new enzyme-labile group called S-acyl-3-thiopropyl group (SATP) has been synthesized from allylic esters of phosphonate. After demonstration of the enzyme-labile character of the SATP in cellular extracts, it has been introduced onto the phosphonate moiety of PFA (Foscarnet) to
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