LO1280

LOPAC^®1280

• Synonym(s): Library of Pharmacologically Active Compounds
• UNSPSC Code: 12352200

Properties

• form: liquid
• Quality Level: 100
• shipped in: dry ice
• storage temp.: −20°C

Description

General description

Compounds are arranged in 96-well format in 16 racks of 80, one compound per well (250 μl at 10 mM in DMSO).

Application

LOPAC^®1280 has been used:

• in the screening of novel inhibitors for chemotaxis/ migration using Dictyostelium as a model
• to test the ability to modulate and to measure forskolin-stimulated cAMP levels in CHO-hCB₂ cells and to modulate ligand-induced receptor/β-arrestin interaction
• in screening of small molecules for activating bone morphogenetic protein (BMP) signaling
• in screening of compounds that plays a role in regulating subcellular localization of nitric oxide associated protein 1 (NOA1) protein

Features and Benefits

Includes the latest, drug-like molecules in the fields of Cell Signaling & Neuroscience:

• Apoptosis
• G Proteins & Cyclic Nucleotides
• Gene Regulation & Expression
• Ion Channels
• Lipid Signaling
• Multi-Drug Resistance
• Neurotransmission
• Phosphorylation

SDFile provided to construct a database containing:

• Structure
• Primary Name
• Secondary Name
• Pharmacological Activity
• Product Number
• Rack Position

Collection of 1,280 Pharmacologically-Active Sigma Compounds

To request a list of components, please visit sigma.com/LOPAC

Other Notes

For sale in the U.S. only. Customers outside of the U.S. should refer to product code LO3300.

Legal Information

LOPAC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS05,GHS06,GHS08,GHS09
• Signal Word: Danger
• Hazard Statements: H300 + H310 + H330 - H314 - H317 - H334 - H340 - H350 - H360FD - H362 - H371 - H373 - H410
• Precautionary Statements: P263 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Lact. - Muta. 1B - Repr. 1A - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT RE 2 - STOT SE 2
• Storage Class Code: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): 188.6 °F - closed cup
• Flash Point(C): 87 °C - closed cup