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Safety Information

L4129

Sigma-Aldrich

L-α-Lysophosphatidylcholine from egg yolk

≥99%, Type I, powder

Synonym(s):

1-Acyl-sn-glycero-3-phosphocholine, L-α-Lysolecithin

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About This Item

CAS Number:
9008-30-4
EC Number:
232-715-0
MDL number:
MFCD00131444
UNSPSC Code:
12352211
NACRES:
NA.25

biological source

egg yolk

Quality Level

200

description

zwitterionic

type

Type I

Assay

≥99%

form

powder

color

white

functional group

phospholipid

lipid type

phosphoglycerides

shipped in

ambient

storage temp.

−20°C

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Application

L-α-Lysophosphatidylcholine from egg yolk has been used:
  • as a surfactant
  • as a media supplement and in Staphylococcus aureus inhibition assay in dermatitis
  • as a demyelinating agent for nerve
  • as a component in sperm nuclei preparation buffer

Biochem/physiol Actions

Lysophosphatidylcholine is a major component of oxidized low density lipoproteins, and has been implicated in various inflammatory reactions, including atherosclerosis. It is used to demyelinate spinal neurons and study the processes underlying remyelination. It activates protein kinase C, p38 MAP kinase, p42 MAP Kinase, and the jun kinase (JNK) pathway, and stimulates transcription of c-jun. Lysophosphatidylcholine accumulates during cardiac ischemia and may induce arrhythmias by uncoupling gap junction communication, and increase ischemic damage by enhancing Na+ loading in cardiac myocytes. It also activates TREK1, TREK2 and TRAAK K+ channels.

Quality

Contains primarily palmitic and stearic acids.

Preparation Note

Prepared by the action of phospholipase A on egg L-α-phosphatidylcholine.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

L4129-BULK:
L4129-VAR:
L4129-500MG:
L4129-5G:
L4129-25MG:
L4129-100MG-KC:
L4129-100MG:
L4129-1G:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Christopher E McMurran et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(50), 25311-25321 (2019-11-20)
The microbiota is now recognized as a key influence on the host immune response in the central nervous system (CNS). As such, there has been some progress toward therapies that modulate the microbiota with the aim of limiting immune-mediated demyelination
Lauri J Lehto et al.
Frontiers in neuroscience, 11, 433-433 (2017-08-22)
In this work a new MRI modality entitled Relaxation Along a Fictitious Field in the rotating frame of rank 4 (RAFF4) was evaluated in its ability to detect lower myelin content in lysophosphatidyl choline (LPC)-induced demyelinating lesions. The lesions were
Isolation and demembranation of Xenopus sperm nuclei
Hazel JW and Gatlin JC
Cold Spring Harbor Protocols (2018)
RP-CARS: label-free optical readout of the myelin intrinsic healthiness
de Vito G, et al.
Optics Express, 22(11), 13733-13743 (2014)
Transplantation of human skin microbiota in models of atopic dermatitis
Myles IA, et al.
JCI insight, 1(10), 031712-031712 (2016)
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