Skip to Content
Merck
All Photos(2)

Key Documents

View All Documentation

Safety Information

L4021

Sigma-Aldrich

Prolactin human

recombinant, expressed in E. coli, lyophilized powder, BioReagent, suitable for cell culture, >97% (SDS-PAGE)

Synonym(s):

hPRL, LTH, Lactogenic Hormone, Luteotropic Hormone, PRL

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

CAS Number:
9002-62-4
MDL number:
MFCD00131553
UNSPSC Code:
51111800
NACRES:
NA.77
form:
lyophilized powder
Assay:
>97% (SDS-PAGE)

recombinant

expressed in E. coli

Quality Level

200

description

200 amino acid residue methionyl form of mature, recombinant human prolactin (amino acid residues 29-227).

product line

BioReagent

Assay

>97% (SDS-PAGE)

form

lyophilized powder

potency

0.030-0.300 ng/mL EC50

mol wt

predicted mol wt ~24 kDa

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

solubility

water: 0.5000 mL, clear, colorless

UniProt accession no.

P01236

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... PRL(5617)

Application

Use in cell culture applications to study prolactin regulation of cell signaling and gene expression.

Biochem/physiol Actions

Prolactin is a neuroendocrine hormone. The prolactin receptor is a transmembrane glycoprotein that belongs to the cytokine hematopoietic receptor family. A large number of cells and organs express the receptor, including B cells, T cells, macrophages, monocytes, and neutrophils. Prolactin signal transduction involves the JAK/STAT families and the src kinase family. Induces lactation; inhibits secretion of gonadotropins; release is inhibited by dopamine.

Other Notes

Contains an N-terminal methionine not present in the natural product.

Physical form

Lyophilized from a solution in 10 mM phosphate and 50 mM sodium chloride, pH 8.0.

Reconstitution

It is recommended that sterile 4 mM HCl containing 1 mg/mL bovine serum albumin be added to the vial to prepare a stock solution of no less than 100 μg/mL.

Analysis Note

The biological activity is assayed by proliferation of the rat lymphoma cell line, Nb2-11.

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H360

Precautionary Statements

P201 - P308 + P313

Hazard Classifications

Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

L4021-50UG:
L4021-50UG-PW:
L4021-VAR:
L4021-BULK:

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
099M4151V
11190332
096M4079V
045M4103V
11140623

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 1

1 of 1

Hydrocortisone BioReagent, suitable for cell culture

Sigma-Aldrich

H0888

Hydrocortisone

G Bellone et al.
Journal of cellular physiology, 163(2), 221-231 (1995-05-01)
The pituitary hormone prolactin (Prl) is known to act as a local regulator of immune cell function, and Prl-binding receptors (Prl-R) have been described to share distinctive features with the members of the newly described cytokine/hemopoietin receptor superfamily. Here we
Extrapituitary prolactin: distribution, regulation, functions, and clinical aspects.
N Ben-Jonathan et al.
Endocrine reviews, 17(6), 639-669 (1996-12-01)
Khalid Bajou et al.
Nature medicine, 20(7), 741-747 (2014-06-16)
The N-terminal fragment of prolactin (16K PRL) inhibits tumor growth by impairing angiogenesis, but the underlying mechanisms are unknown. Here, we found that 16K PRL binds the fibrinolytic inhibitor plasminogen activator inhibitor-1 (PAI-1), which is known to contextually promote tumor
Etienne Delgrange et al.
European journal of endocrinology, 170(1), 31-38 (2013-10-04)
To characterise distinctive clinical features of giant prolactinomas in women. A multicentre, retrospective case series and literature review. We collected data from 15 female patients with a pituitary tumour larger than 4 cm and prolactin levels above 1000 μg/l and
Akie Nakamura et al.
The Journal of clinical endocrinology and metabolism, 98(10), E1682-E1691 (2013-08-24)
Congenital central hypothyroidism (C-CH) is a rare disease. We investigated the molecular basis of unexplained C-CH in 4 Japanese boys. C-CH was diagnosed by low free T4 and/or T3 and low basal TSH concentrations. We used whole-exome sequencing of one
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service