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K3627

Sigma-Aldrich

Kallikrein from porcine pancreas

≥40 units/mg protein

Synonym(s):

Kininogenase, Kininogenin

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About This Item

CAS Number:
9001-01-8
Enzyme Commission number:
3.4.21.35 (BRENDA, IUBMB)
EC Number:
232-574-5
MDL number:
MFCD00131428
UNSPSC Code:
12352204
NACRES:
NA.54

form

solid

Quality Level

200

specific activity

≥40 units/mg protein

storage temp.

2-8°C

General description

Kallikrein exists as an inactive prokallikrein in the porcine pancreas. The porcine kallikrein gene region is localized on chromosome 6q12-q21.

Application

Kallikrein from porcine pancreas has been used:
  • as a matrix metalloproteinase-9 (MMP-9) zymogen activator
  • as a component of cell culture to test its effect on rat subventricular zone (SVZ) cells and oligodendrocyte progenitor cells (OPC) proliferation and survival
  • as a model enzyme to track kinetic data and visual detection limits of hydrolysis by hydrolytic enzymes in the two-phases array

Biochem/physiol Actions

Kallikrein active forms are generated by the enzymatic action of trypsin. It is a serine protease that mediates the activation of growth factors and substrates.

Unit Definition

One unit will hydrolyze 1.0 μmole of Nα-benzoyl-L-arginine ethyl ester (BAEE) to Nα-benzoyl-L-arginine and ethanol per min at pH 8.7 at 25°C.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H315,H319,H334,H335

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

K3627-VAR:
K3627-1KU:
K3627-BULK:
K3627-250UN:
K3627-50UN:

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Certificates of Analysis (COA)

Lot/Batch Number
SLCG3313
SLBV6559
SLBS8463
SLBS2807V
SLBQ8653V

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S C Fernando et al.
Genomics, 89(3), 429-438 (2007-01-11)
Kallikreins belong to a family of serine proteases that are widespread throughout living organisms, expressed in diverse tissue-specific patterns, and known to have highly diverse physiological functions. The 15 human and 24 mouse kallikreins have been implicated in pathophysiology of
Gabriel Rosenblum et al.
Journal of the American Chemical Society, 129(44), 13566-13574 (2007-10-13)
Activation of matrix metalloproteinase zymogen (pro-MMP) is a vital homeostatic process, yet its molecular basis remains unresolved. Using stopped-flow X-ray spectroscopy of the active site zinc ion, we determined the temporal sequence of pro-MMP-9 activation catalyzed by tissue kallikrein protease
M G Cotenescu et al.
Journal of biotechnology, 76(1), 33-41 (2000-04-28)
A new assay is described that monitors hydrolysis with the concurrent transfer of a solvatochromic dye across an oil-water barrier. Through the appropriate design, this transfer is accompanied by a 10(6) gain in fluorescence. This response can be used to
Prostate-specific antigen kallikrein is not a marker of non-ST elevation acute coronary syndrome.
Alberto Dominguez-Rodriguez et al.
International journal of cardiology, 149(1), 141-142 (2011-03-05)
Hongmei Yu et al.
Molecular and cellular biochemistry, 352(1-2), 65-75 (2011-02-11)
Mucus hypersecretion is an important manifestation in patients with chronic inflammatory airway diseases. Mucin 5AC (MUC5AC) is a major component of airway mucus. MUC5AC expression is regulated by epidermal growth factor receptor (EGFR) which can be activated by reactive oxygen
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