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Safety Information

K2644

Sigma-Aldrich

Kisspeptin-234 trifluoroacetate salt

≥95% (HPLC)

Synonym(s):

kisspeptin-10 peptide 234

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About This Item

Empirical Formula (Hill Notation):
C63H78N18O13 · xC2HF3O2
CAS Number:
1848962-29-7
Molecular Weight:
1295.41 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.32

Assay

≥95% (HPLC)

form

film

color

colorless to white

solubility

H2O: >1 mg/mL

storage temp.

−20°C

Biochem/physiol Actions

Kisspeptin-234 is a 10-amino acid peptide antagonist with potent neutral antagonist activity at GPR-54 and competes directly at the Kisspeptin-10 binding site. Kisspeptin-234 is the first reported antagonist for the kisspeptin-1/GPR-54 signaling system.

Gonadotropin-releasing hormone (GnRH) modulates the hypothalamic-pituitary-gonadal axis, enabling the brain to control reproductive processes. Kisspeptin-1 is a peptide neurotransmitter released from afferent neurons onto GnRH neurons, where it binds to and activates to the orphan receptor GPR-54 to regulate release of GnRH. Regulation of kisspeptin/GPR-54 signaling presents an opportunity for reproductive therapeutics above the level of GnRH and gonadotropin secretion. Pharmacological and selective tools are needed to better understand kisspeptin-1/GPR-54 signaling. Analogs of kisspeptin-10, a 10-amino acid portion of kisspeptin-1, were designed to be full and neutral antagonists of GPR-54.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

K2644-1MG:
K2644-VAR:
K2644-BULK:

Certificates of Analysis (COA)

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