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Safety Information

I9404

Sigma-Aldrich

Interleukin-10/Fc Chimera (non-lytic) human

>98% (SDS-PAGE), recombinant, expressed in NS.1 cells, buffered aqueous solution

Synonym(s):

IL-10:Fc (non-lytic) human

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About This Item

MDL number:
MFCD03457245
UNSPSC Code:
51111800
NACRES:
NA.32

biological source

human

Quality Level

200

recombinant

expressed in NS.1 cells

Assay

>98% (SDS-PAGE)

form

buffered aqueous solution

mol wt

98 kDa

packaging

pkg of 10 μg

impurities

endotoxin, tested

UniProt accession no.

P22301

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... IL10(3586)

General description

The gene IL-10 (interleukin-10) is mapped to human chromosome 1q31-32. It is secreted by monocytes and lymphocytes.

Biochem/physiol Actions

IL-10 (interleukin-10) is an anti-inflammatory cytokine. High levels of IL-10 are present in late syphilis. It suppresses Th1 (T helper) cytokines. IL-10 also controls the differentiation and proliferation of T cells, B cells, natural killer cells, antigen-presenting cells and mast cells.
Possesses the biological function of the IL-10 moiety and a prolonged circulating half-life determined by the Fc domain.

Other Notes

Dimeric fusion protein consisting of human IL-10 fused to mutant human IgG1 Fc.

Physical form

Solution in 0.2 μm filtered phosphate buffered saline, pH 7.4.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

I9404-10UG:
I9404-10UG-PW:
I9404-VAR:
I9404-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
SLCL7748
SLCD3152
071K1091

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Maciej Pastuszczak et al.
Human immunology, 76(7), 469-472 (2015-06-24)
Interleukin 10 (IL-10) is a potent anti-inflammatory cytokine. Increased production of IL-10 has been found in late syphilis, presumably creating favorable conditions for bacteria persistence. Single-nucleotide polymorphisms (SNPs) within the promoter of IL-10 gene have been found to influence IL-10
Lucia Elena Alvarado-Arnez et al.
PloS one, 10(9), e0136282-e0136282 (2015-09-05)
Leprosy is a chronic infectious disease that depends on the interplay of several factors. Single nucleotide polymorphisms (SNPs) in host immune related genes have been consistently suggested as participants in susceptibility towards disease. Interleukin-10 (IL-10) is a crucial immunomodulatory cytokine
C Gérard et al.
The Journal of experimental medicine, 177(2), 547-550 (1993-02-01)
Because of its ability to efficiently inhibit in vitro cytokine production by activated macrophages, we hypothesized that interleukin (IL) 10 might be of particular interest in preventing endotoxin-induced toxicity. We therefore examined the effects of IL-10 administration before lipopolysaccharide (LPS)
Manal Mohamed Makhlouf et al.
Laboratory medicine, 45(3), 211-219 (2014-07-23)
Immune thrombocytopenic purpura (ITP) is an acquired autoimmune disorder caused by the production of antiplatelet antibodies. These autoantibodies opsonize platelets for splenic clearance, resulting in low levels of circulating platelets. Interleukin 4 (IL4) and interleukin 10 (IL10) are important immunoregulatory

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