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Safety Information

I8409

Sigma-Aldrich

Anti-Interleukin-7 Receptor α/CD127 antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-CD127, Anti-CDW127, Anti-IL7R, Anti-ILRA

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About This Item

MDL number:
MFCD01864808
UNSPSC Code:
51111800
NACRES:
NA.41

biological source

goat

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human

technique(s)

flow cytometry: 5.0-10.0 μg/mL
western blot: 0.1-0.2 μg/mL

UniProt accession no.

P16871

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IL7R(3575)

General description

Interleukin-7 (IL-7) is a stromal-cell derived cytokine that is important in the development of adaptive immunity and maintenance of T cells and B cells. The cognate receptor that binds IL-7 is the IL-7 receptor complex, made up of IL-7 R α chain and a γ chain. The expression of IL-7 R is restricted to immature B cells, mature T cells and thymocytes. The binding of IL-7 to its receptor triggers a variety of tightly regulated signalling pathways that are critical for cell survival, proliferation, differentiation and uptake of glucose. The signalling pathways that participate in mediating the effects of IL-7 R are JAK/STAT and PI3K. Additionally the effect of IL-7 on cell cycle is due to the modulation of proteins p27kip1 and Cdc25A. Reports implicate IL-7 R in glucose metabolism and cell size as it modulates the effects of GLUT4
Anti-interleukin-7 receptor α/CD127 recognizes human interleukin-7.

Immunogen

purified, NSO cell-derived recombinant human interleukin-7 soluble receptor α.

Application

Anti-interleukin-7 receptor α/CD127 antibody may be used for immunoblotting at a working concentration of 0.1-0.2 μg/ml. For flow cytometry, the recommended concentration is 5-10 μg/ml.

Target description

Interleukin-7 Receptor α/CD127 encodes a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

I8409-VAR:
I8409-BULK:
I8409-100UG:
I8409-100UG-PW:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells
Barata JT et al
Journal of Experimental Marine Biology and Ecology, 200, 659-669 (2004)
C Kittipatarin et al.
Cell cycle (Georgetown, Tex.), 5(9), 907-912 (2006-04-22)
A balance between survival and proliferative signals maintains a constant number of T lymphocytes that populate the mammalian immune system, a process termed "homeostasis". Central to this process is the availability of a stromal cell product--the cytokine interleukin-7 (IL-7). We
C Pallard et al.
Immunity, 10(5), 525-535 (1999-06-15)
Here, we define the IL-7R-activated signal that promotes survival and proliferation of T cell progenitors and demonstrate that it is distinct from the signals that induce differentiation. We show that IL-7 activates PKB and STAT5 in human thymocytes. Into T
Christina Kittipatarin et al.
Cytokine, 39(1), 75-83 (2007-09-05)
The signaling processes that maintain the homeostatic proliferation of peripheral T-cells and result in their self-renewal largely remain to be elucidated. Much focus has been placed on the anti-apoptotic function of the cytokine, interleukin-7 (IL-7), during T-cell development. But a
Interleukin-7: from bench to clinic.
Terry J Fry et al.
Blood, 99(11), 3892-3904 (2002-05-16)
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