Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

Safety Information

I6410

Sigma-Aldrich

ISCK03

≥98% (HPLC), solid

Synonym(s):

Benzenesulfonamide,4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl], [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C19H21N3O2S
CAS Number:
945526-43-2
Molecular Weight:
355.45
MDL number:
MFCD12031591
UNSPSC Code:
12352200
PubChem Substance ID:
329815393
NACRES:
NA.77

Assay

≥98% (HPLC)

form

solid

color

yellow

solubility

DMSO: ≥20 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc2ccc(cc2)-n3ccnc3

InChI

1S/C19H21N3O2S/c1-19(2,3)15-4-10-18(11-5-15)25(23,24)21-16-6-8-17(9-7-16)22-13-12-20-14-22/h4-14,21H,1-3H3

InChI key

XQABBHBFHWHMKF-UHFFFAOYSA-N

Biochem/physiol Actions

ISCK03 inhibits in vitro phosphorylation of c-Kit in a dose dependent manner.
ISCK03 inhibits in vitro phosphorylation of c-Kit in a dose dependent manner. ISCK03 inhibits SCF (stem cell factor)-induced c-kit phosphorylation in 501mel human melanoma cells. Complete inhibition was observed with 1 and 5 μM ISCK03.

Features and Benefits

This compound is featured on the PDGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

I6410-25MG:
I6410-5MG:
I6410-BULK:
I6410-VAR:

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
098K4624V
098K4624

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Hiroko Morimoto et al.
PloS one, 4(11), e7909-e7909 (2009-11-26)
Spermatogonial stem cells (SSCs) continuously undergo self-renewal division to support spermatogenesis. SSCs are thought to have a fixed phenotype, and development of a germ cell transplantation technique facilitated their characterization and prospective isolation in a deterministic manner; however, our in
Yuan Ma et al.
Cell cycle (Georgetown, Tex.), 19(16), 2074-2080 (2020-07-14)
Neurogenic bladder (NB) is a type of double renal dysfunction caused by nerve lesions. The interstitial cells of Cajal (ICC) damage are involved in bladder dysfunction. The aim of this study is to investigate the effect of stem cell factor
Jin Man Kim et al.
Development (Cambridge, England), 148(6) (2021-03-05)
The actomyosin complex plays crucial roles in various life processes by balancing the forces generated by cellular components. In addition to its physical function, the actomyosin complex participates in mechanotransduction. However, the exact role of actomyosin contractility in force transmission
Keai Sinn Tan et al.
Biology open, 4(5), 596-607 (2015-04-19)
Fetal spleen is a major hematopoietic site prior to initiation of bone marrow hematopoiesis. Morphologic analysis suggested erythropoietic activity in fetal spleen, but it remained unclear how erythropoiesis was regulated. To address this question, we performed flow cytometric analysis and

Articles

PDGFR

Sigma-Aldrich offers many products related to PDGFR for your research needs.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service