HPA052673
Anti-SLC7A5 antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Synonym(s):
Anti-CD98, Anti-D16S469E, Anti-E16, Anti-LAT1, Anti-MPE16
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All Photos(4)
About This Item
UNSPSC Code:
12352203
Human Protein Atlas Number:
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
enhanced validation
orthogonal RNAseq
Learn more about Antibody Enhanced Validation
technique(s)
immunohistochemistry: 1:50-1:200
immunogen sequence
AEEKEEAREKMLAAKSADGSAPAGEGEGVTLQRNI
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SLC7A5(8140)
General description
SLC7A5 (solute carrier family 7 member 5) is a sodium-independent transporter, located on human chromosome 16q24.2. It is usually expressed in the membrane of invasive breast cancer cells. SLC7A5 is also known as LAT1 (L-type amino acid transporter 1).
Immunogen
solute carrier family 7 (amino acid transporter light chain, L system), member 5
Application
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Anti-SLC7A5 antibody has been used in immunofluorescence microscopy.
Anti-SLC7A5 antibody has been used in immunofluorescence microscopy.
Biochem/physiol Actions
SLC7A5 (solute carrier family 7 member 5) serves as a crucial transporter of amino acids in human thymic carcinoma cells. It helps to maintain intracellular leucine, a master regulator of the mammalian target of rapamycin complex1 (mTORC1) signalling pathway. SLC7A5 helps to absorb essential amino acids into cells.
Features and Benefits
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
Linkage
Corresponding Antigen APREST84340
Physical form
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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The amino acid transporter SLC7A5 confers a poor prognosis in the highly proliferative breast cancer subtypes and is a key therapeutic target in luminal B tumours.
El Ansari R, et al.
Breast Cancer Research, 20(1), 21-21 (2018)
LAT1 acts as a crucial transporter of amino acids in human thymic carcinoma cells.
Hayashi K, et al.
Journal of Pharmacological Sciences, 132(3), 201-204 (2016)
Yasuhiro Saito et al.
Communications biology, 5(1), 403-403 (2022-05-03)
Estrogen receptor (ER) positive breast cancer represents 75% of all breast cancers in women. Although patients with ER+ cancers receive endocrine therapies, more than 30% develop resistance and succumb to the disease, highlighting the need to understand endocrine resistance. Here
Characterization of 5-(2-
Ahmed Abbas et al.
F1000Research, 5, 1851-1851 (2016-12-06)
Masato Asanuma et al.
PloS one, 9(9), e106362-e106362 (2014-09-05)
L-DOPA is therapeutically efficacious in patients with Parkinson's disease (PD), although dopamine (DA) neurons are severely degenerated. Since cortical astrocytes express neutral amino acid transporter (LAT) and DA transporter (DAT), the uptake and metabolism of L-DOPA and DA in striatal
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