H4914

Honokiol

≥98% (HPLC), powder

• Synonym(s): 5,3′-Diallyl-2,4′-dihydroxybiphenyl, NSC 293100
• Empirical Formula (Hill Notation): C₁₈H₁₈O₂
• CAS Number: 35354-74-6
• Molecular Weight: 266.33
• MDL number: MFCD00016674
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724501
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• solubility: DMSO: 36 mg/mL
• antibiotic activity spectrum: Gram-positive bacteria; neoplastics
• Mode of action: DNA synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: Oc1ccc(cc1CC=C)-c2cc(CC=C)ccc2O
• InChI: 1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2
• InChI key: FVYXIJYOAGAUQK-UHFFFAOYSA-N

Description

General description

Honokiol exhibits analgesic, antithrombotic, antispasmodic, antidepressant, antimicrobial and neuroprotective effects. It regulates gamma-aminobutyric acid (GABA) A receptors. Honokiol is associated with an increased risk of bleeding. It prevents platelet aggregation, protects myocardium from ischemic damage and inhibits ventricular arrhythmia.

Application

Honokiol has been used:

• to study its effects on plasmid hSirt3^102-399 deacetylation activity
• as an antioxidant to study its cytoprotective role in human ovarian cancer cells (SKOV-3) and Chinese hamster ovary cells (CHOK1)
• to explore its effects on oxidative stress and mitochondrial dysfunction via a sirt3-dependent manner
• for intracerebroventricular (ICV) cannulation

Biochem/physiol Actions

Honokiol is a natural biphenyl neolignan from magnolia extract. It is antiangiogenic, antitumor, and anxiolytic.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Pictograms: GHS05,GHS09
• Signal Word: Danger
• Hazard Statements: H318 - H411
• Precautionary Statements: P273 - P280 - P305 + P351 + P338 - P391 - P501
• Hazard Classifications: Aquatic Chronic 2 - Eye Dam. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves