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Safety Information

H2667

Sigma-Aldrich

Histone H4 human

Synonym(s):

Histone, Human

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About This Item

CAS Number:
1523001-32-2
UNSPSC Code:
12352202
NACRES:
NA.25

biological source

human

Quality Level

200

recombinant

expressed in E. coli

form

liquid

concentration

1 mg/mL

UniProt accession no.

P62805

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... H4C1(121504)

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General description

Histones are highly basic chromatin proteins. They tightly pack and organize eukaryotic DNA into nucleosomes. Nucleosomes consist of a histone octamer made of a tetramer of histones H3 and H4 with two dimers of histones H2A and H2B, wherein the 147 DNA base pairs are wrapped around this histone complex.

Application

Histone H4 human has been used in far-western blot analysis for protein identification. It has also been used in the preparation of standard protein solution for protein digestion.

Biochem/physiol Actions

Histones regulate transcription, DNA replication, DNA repair, and recombination.

Other Notes

Supplied as 1 mg/mL in 20 mM NaPO4, pH 7.0, 0.3 M NaCl, 1 mM EDTA

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Hazard Classifications

Eye Irrit. 2

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PRTR

Class I Designated Chemical Substances

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

H2667-100UG-PW:
H2667-100UG:
H2667-VAR:
H2667-BULK:

Certificates of Analysis (COA)

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Khoa N Pham et al.
The journal of physical chemistry. B, 125(19), 4977-4986 (2021-05-12)
Histones are highly basic chromatin proteins that tightly package and order eukaryotic DNA into nucleosomes. While the atomic structure of the nucleosomes has been determined, the three-dimensional structure of DNA-free histones remains unresolved. Here, we combine tandem nonlinear and linear
Apurva Bhardwaj et al.
International journal of molecular sciences, 22(1) (2021-01-07)
Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3) is an essential protein that regulates cellular processes such as cell proliferation, apoptosis, and differentiation. It is known to bind with several proteins to carry out various cellular functions. In this study, we

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