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Safety Information

H0417

Sigma-Aldrich

Heparin Cofactor II from human plasma

aqueous glycerol solution, ≥90% (SDS-PAGE)

Synonym(s):

HCF2, HCII, SERPIND1

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About This Item

CAS Number:
81604-65-1
MDL number:
MFCD00285907
UNSPSC Code:
12352202
NACRES:
NA.61

biological source

human plasma

Quality Level

200

Assay

≥90% (SDS-PAGE)

form

aqueous glycerol solution

mol wt

~66 kDa
 ~66 kDa

NCBI accession no.

NP_000176

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... SERPIND1(3053)

Biochem/physiol Actions

Heparin cofactor II (HCII), a member of the serpin superfamily, is a serine protease inhibitor that rapidly inactivates thrombin in the presence of dermatan sulfate, heparan sulfate, or heparin. In addition to its role in coagulation regulation, HCII may also participate in inflammation, atherosclerosis, and wound repair. For example, leukocyte-mediated degradation of HCII releases peptides that are chemotactic for neutrophils and monocytes which may promote acute inflammation and wound repair. It has also been reported that HCII and dermatan sulfate levels are elevated in pregnancy, suggesting that HCII may be protective against thrombosis during pregnancy.
Serine protease that inhibits thrombin, α-chymotrypsin, neutrophil cathepsin G, and Streptomyces griseus protease B.

Unit Definition

HCII is tested for activity using a Thrombin inhibition assay. One unit will inhibit one NIH unit of Thrombin.

Physical form

50% aqueous glycerol solution (vol/vol)

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

H0417-VAR:
H0417-BULK:
H0417-100UG:
H0417-100UG-PW:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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