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Safety Information

GW20074F

Sigma-Aldrich

Anti-Ceruloplasmin antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Ferroxidase

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About This Item

MDL number:
MFCD00162219
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

manufacturer/tradename

Genway 15-288-20074F

technique(s)

indirect ELISA: suitable
western blot: suitable

NCBI accession no.

NP_000087.1

UniProt accession no.

P00450

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CP(1356)

Immunogen

Ceruloplasmin native protein.
Immunogen Sequence: GI # 4557485, sequence 1-1065

Application

Anti-Ceruloplasmin antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Biochem/physiol Actions

Ceruloplasmin (or caeruloplasmin) is a ferroxidase enzyme encoded by the CP gene in humans. It is a ferroxidase present in the cerebrospinal fluid (CSF). CP is associated with promoting the function of integrin binding, signaling and cell adhesion. The CP level is correlated negatively and indirectly with inflammation as well as fibrosis stages in male patients with chronic hepatitis B (CHB). It decreases the nitric oxide bioavailability in blood and is associated with cardiovascular disease (CVD).

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

GW20074F-VAR:
GW20074F-50UG:
GW20074F-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Da-Wu Zeng et al.
PloS one, 8(10), e77942-e77942 (2013-11-28)
This study aimed to investigate associations between ceruloplasmin (CP) levels, inflammation grade and fibrosis stages in patients with chronic hepatitis B (CHB) and to establish a noninvasive model to predict cirrhosis. Liver biopsy samples and sera were collected from 198
Marco Barbariga et al.
The Journal of biological chemistry, 289(6), 3736-3748 (2013-12-25)
Asparagine deamidation occurs spontaneously in proteins during aging; deamidation of Asn-Gly-Arg (NGR) sites can lead to the formation of isoAsp-Gly-Arg (isoDGR), a motif that can recognize the RGD-binding site of integrins. Ceruloplasmin (Cp), a ferroxidase present in the cerebrospinal fluid
Razvan T Dadu et al.
Circulation. Heart failure, 6(5), 936-943 (2013-07-19)
Ceruloplasmin (Cp) decreases nitric oxide bioavailability in blood and has been associated with cardiovascular disease (CVD) in clinical studies. We assessed the associations between Cp and incident heart failure (HF), death, and CVD in the Atherosclerosis Risk in Communities (ARIC)
Lingli Jiang et al.
American journal of physiology. Gastrointestinal and liver physiology, 301(5), G877-G886 (2011-08-20)
The Menkes copper ATPase (Atp7a) and metallothionein (Mt1a) are induced in the duodenum of iron-deficient rats, and serum and hepatic copper levels increase. Induction of a multi-copper ferroxidase (ceruloplasmin; Cp) has also been documented. These findings hint at an important
Perungavur N Ranganathan et al.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 25(4), 687-695 (2012-02-22)
Discovered over a decade ago, hephaestin (Heph) has been implicated as a ferroxidase (FOX) vital for intestinal iron absorption. Stringent structural or kinetic data derived from purified, native protein is however lacking, leading to the hypothesis that an alternate, undiscovered
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