Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

Safety Information

G7420

Sigma-Aldrich

Galectin-1 human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), lyophilized powder

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

MDL number:
MFCD05665409
UNSPSC Code:
12352202
NACRES:
NA.25

biological source

human

Quality Level

200

recombinant

expressed in E. coli

Assay

≥95% (SDS-PAGE)

form

lyophilized powder

UniProt accession no.

P09382

application(s)

cell analysis

storage temp.

−20°C

Gene Information

human ... LGALS1(3956)

General description

Galectin-1 is a member of the family of animal lectins, which selectively binds β-galactoside residues.

Application

A common function of galectins is to cross-link structures containing N-acetyl-lactosamine located at the cell surface and within the extracellular matrix. They also possess hemagglutination activity, which is attributable to their bivalent carbohydrate binding properties. They have variable affinity for more complex oligosaccharides. Other activities of galectin-1 include cell differentiation and inhibition of CD45 protein phosphatase activity.

Biochem/physiol Actions

Galectin-1 has been implicated in metastasis and aggregation of cancer cells based on its association with the glycoprotein 90K. Galectin-1 may play a significant role in cancer through apoptosis, cell adhesion, migration, cell cycle regulation and tumor evasion of immune responses.
Galectin-1 has been implicated in metastasis and aggregation of cancer cells based on its association with the glycoprotein 90K. Galectin-1 may play a significant role in cancer through apoptosis, cell adhesion and migration, regulation of the cell cycle and tumor evasion of immune responses.

Physical form

Lyophilized from a 5 mg/mL solution in phosphate buffered saline containing 8 mM DTT and 150 mM lactose.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

G7420-VAR:
G7420-150UG:
G7420-BULK:
G7420-150UG-PW:
G7420-250UG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

F Archambeaud-Mouveroux et al.
Gastroenterologie clinique et biologique, 11(1), 93-95 (1987-01-01)
A case of secondary syphilitic hepatitis is reported. A 49-year old woman was admitted for weight-loss, fever, hepatomegaly and splenomegaly. Diagnosis of syphilitic hepatitis was based on cholestasis associated with positive serologic tests for syphilis without other immunological disturbances. Biopsy
Antonino Grassadonia et al.
Glycoconjugate journal, 19(7-9), 551-556 (2004-02-06)
Galectins and their ligands have been implicated in cell transformation and cancer metastasis, and found to have prognostic value. Mac-2 BP, also known as 90K, is a highly glycosylated, secreted protein extensively studied in human cancer, which binds galectin-1, galectin-3
Zanka Bojić-Trbojević et al.
Histochemistry and cell biology, 142(5), 541-553 (2014-05-24)
Mucins are multifunctional highly glycosylated proteins expressed by the female reproductive tract. Differential expression of MUC1 and MUC15 has been shown in trophoblast. This study was undertaken to establish the distribution of mucin(s) in cytotrophoblast cell cultures using anti-bovine submaxillary
V D Yakushina et al.
Molecular and cellular biochemistry, 398(1-2), 245-249 (2014-10-09)
CD4(+) T cells orchestrate the immune response by differentiating into T helper (Th) or regulatory (Treg) cell subsets that secrete distinct sets of cytokines. They also play a critical role in the pathogenesis of autoimmunity, asthma, allergy and, likely, cancer.
Sandra Thiemann et al.
The Journal of biological chemistry, 290(37), 22662-22677 (2015-07-29)
During inflammation, dendritic cells emigrate from inflamed tissue across the lymphatic endothelium into the lymphatic vasculature and travel to regional lymph nodes to initiate immune responses. However, the processes that regulate dendritic cell tissue egress and migration across the lymphatic
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service