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F4503

Sigma-Aldrich

Ferritin from equine spleen

Type I, saline solution

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About This Item

CAS Number:
9007-73-2
MDL number:
MFCD00081593
UNSPSC Code:
12352202
NACRES:
NA.77

sterility

sterile-filtered

Quality Level

300

type

Type I

form

saline solution

mol wt

H subunit ~21 kDa
L subunit ~19 kDa

color

red to brown

cation traces

Cd: ≤1% (as % of ferritin)

storage temp.

2-8°C

General description

A shell of 24 protein subunits (apoferritin) and a core Fe 3+ ions with a peptide MW of 440 kDa. Review of the ferritin-like superfamily of iron-storage proteins, virtually ubiquitous in life on earth.

Application

Ferritin from equine spleen has been used:
  • in mycobacterial growth assay
  • in size-exclusion chromatography
  • in labeling of macrophage cells
  • as a reference standard in muon spin spectroscopy

Biochem/physiol Actions

A ubiquitous iron storage protein that plays a key role in iron metabolism. It serves as an intracellular iron reserve (particularly in spleen, liver, intestinal mucosa, and bone marrow) and functions in iron detoxification. Studies have shown that ferritin iron incorporation is mediated by a ferroxidase activity associated with ferritin H subunits and a nucleation center associated with ferritin L subunits. Release of iron from ferritin has an essential role in iron-dependent lipid peroxidation and may contribute to free radical-induced cell damage in vivo. Therefore, by binding iron, ferritin may function as an antioxidant.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

F4503-500MG-PW:
F4503-25MG-PW:
F4503-5G:
F4503-100MG:
F4503-VAR-N:
F4503-BULK-N:
F4503-500MG:
F4503-BULK:
F4503-VAR:
F4503-1G-PW:
F4503-100MG-PW:
F4503-1G:
F4503PROC:
F4503-PH:
F4503-25MG:

Certificates of Analysis (COA)

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Shi Qiu et al.
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Adipocyte model of Mycobacterium tuberculosis infection reveals differential iron availability to bacilli in the lipid rich caseous environment
Nandy A, et al.
Infection and Immunity, IAI-00041 (2018)
Sella Kim et al.
Journal of molecular biology, 428(24 Pt B), 5007-5018 (2016-11-03)
Iron and oxygen chemistry is mediated by iron proteins for many biological functions. Carboxylate-bridged diiron enzymes including ferritin have the common mechanism of oxygen activation via peroxodiferric intermediates. However, the route for iron uptake and the structural identification of intermediates
Defining the Architecture of the Core Machinery for the Assembly of Fe-S Clusters in Human Mitochondria
Methods in Enzymology, 595, 107-160 (2017)
Lucia Bossoni et al.
Magnetic resonance in medicine, 87(3), 1276-1288 (2021-10-17)
To employ an off-resonance saturation method to measure the mineral-iron pool in the postmortem brain, which is an endogenous contrast agent that can give information on cellular iron status. An off-resonance saturation acquisition protocol was implemented on a 7 Tesla
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