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Safety Information

E1411

Sigma-Aldrich

Proline Specific Endopeptidase from Flavobacterium sp.

lyophilized powder, ≥5.0 units/mg solid

Synonym(s):

EndoProC, Endoprolylpeptidase, Endoproteinase Pro-C, PEPase, Prolyl Endopeptidase

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About This Item

UNSPSC Code:
12352204
NACRES:
NA.54

biological source

bacterial (Flavobacterium spp.)

Quality Level

200

form

lyophilized powder

specific activity

≥5.0 units/mg solid

mol wt

~78 kDa

shipped in

dry ice

storage temp.

−20°C

Related Categories

Application

Proline specific endopeptidase is useful for the determination of amino acid sequences of peptides and proteins containing proline residues. Proline specific endopeptidases may be useful in cancer, neurology and diabetes research . Prolyl endopeptidase (PEP) may be used as a drug target for neuropsychiatric diseases such as stress disorder, depression, and schizophrenia .

Biochem/physiol Actions

An endopeptidase is a proteolytic peptidase that breaks peptide bonds of nonterminal amino acids. Product E1411 is specific for proline (Pro). The Prolyl endopeptidase (PEP) mechanism is thought to be an induced fit mechanism, where the native enzyme exists in a conformationally flexible opened state but is changed to a closed state upon substrate binding .

Unit Definition

One unit causes the formation of one micromole of p-nitroaniline per minute under specific pH and temperature conditions.

Physical form

White amorphous lyophilized powder

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

E1411-50UN:
E1411-BULK:
E1411-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
SLCM2397
SLCJ4157
SLCF4196
SLCC5595
SLBW4286

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Min Li et al.
The Journal of biological chemistry, 285(28), 21487-21495 (2010-05-07)
Prolyl peptidases cleave proteins at proline residues and are of importance for cancer, neurological function, and type II diabetes. Prolyl endopeptidase (PEP) cleaves neuropeptides and is a drug target for neuropsychiatric diseases such as post-traumatic stress disorder, depression, and schizophrenia.

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