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Safety Information

E1235

Sigma-Aldrich

EGF human

Xeno-free, recombinant, expressed in HEK 293 cells, suitable for cell culture

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About This Item

UNSPSC Code:
12352202

Quality Level

300

form

lyophilized powder

mol wt

7.3 kDa

technique(s)

cell culture | mammalian: suitable

shipped in

dry ice

storage temp.

-10 to -25°C

General description

Recombinant human Epidermal Growth Factor is small polypeptide of 6.2 kDa protein containing 53 amino acid residues. The EGF gene encodes for a large type I membrane–anchored precursor protein which is cleaved into pro-EGF for generation of peptide hormone EGF. EGF can be found in human platelets, macrophages, urine, saliva, milk, and plasma.

Biochem/physiol Actions

Epidermal Growth Factor (EGF) is a growth factor that plays an important role in the regulation of cell growth, proliferation, and differentiation by binding to its receptor EGFR. Biological activities ascribed to EGF include epithelial development, angiogenesis, inhibition of gastric acid secretion, fibroblast proliferation, and colony formation of epidermal cells in culture.

Preparation Note

For reconstitution: Briefly centrifuge the vial before opening. Reconstitute in water to a concentration of 0.1 mg/mL. Do not vortex. This solution is recommended to store in working aliquots at –20 oC to -80 oC. Store the lyophilized product at –20 oC. The product is stable for at least 2 years as supplied.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

E1235-10UG:
E1235-BULK:
E1235-VAR:
E1235-50UG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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