Skip to Content
Merck
All Photos(1)

Key Documents

Safety Information

D9286

Sigma-Aldrich

Paraoxon-ethyl

≥90%, oil

Synonym(s):

O,O-Diethyl O-(4-nitrophenyl) phosphate, Diethyl p-nitrophenyl phosphate, Paraoxon, Paraoxon-ethyl

Sign Into View Organizational & Contract Pricing


About This Item

Linear Formula:
O2NC6H4OP(O)(OC2H5)2
CAS Number:
Molecular Weight:
275.20
Beilstein:
1915526
EC Number:
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77

Assay

≥90%

form

oil

color

yellow

refractive index

n20/D 1.51 (lit.)

density

1.274 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

CCOP(=O)(OCC)Oc1ccc(cc1)[N+]([O-])=O

InChI

1S/C10H14NO6P/c1-3-15-18(14,16-4-2)17-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3

InChI key

WYMSBXTXOHUIGT-UHFFFAOYSA-N

Gene Information

human ... PON1(5444)

Looking for similar products? Visit Product Comparison Guide

Application

Paraoxon-ethyl has been used as a substrate in paraoxonase (PON) activity assay. It has also been used as a lipase inhibitor to study the effects of anacetrapib on homotypic transfer from high density lipoprotein L3 (HDL3) to HDL2 in vivo.

Biochem/physiol Actions

Potent irreversible acetylcholinesterase inhibitor

Caution

air sensitive: handle under argon

Physical form

Oily liquid

Pictograms

Skull and crossbonesEnvironment

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 1 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

D9286-VAR:
D9286-BULK:
D9286-1G:


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Altered lipoproteins in patients with systemic lupus erythematosus are associated with augmented oxidative stress: a potential role in atherosclerosis
Park JK, et al.
Arthritis Research & Therapy, 18(1), 306-306 (2016)
Association between ethnicity and obesity with high-density lipoprotein (HDL) function and subclass distribution
Woudberg NJ, et al.
Lipids in Health and Disease, 15(1), 92-92 (2016)
Ronit Shiri-Sverdlov et al.
Journal of hepatology, 44(4), 732-741 (2006-02-10)
The molecular mechanisms leading to Non-Alcoholic Steatohepatitis (NASH) are not fully understood. In mice, NASH can be inhibited by fenofibrate, a synthetic agonist for the nuclear receptor peroxisome proliferator activated receptor alpha, which regulates hepatic triglyceride metabolism. This study aimed
Exercise intervention alters HDL subclass distribution and function in obese women
Woudberg NJ, et al.
Lipids in Health and Disease, 17(1), 232-232 (2018)
Elena Grao-Cruces et al.
Biomedicines, 9(11) (2021-11-28)
High-density lipoproteins (HDLs) play an important role in reverse cholesterol transport and present antioxidant properties, among others. In the central nervous system (CNS), there are HDLs, where these lipoproteins could influence brain health. Owing to the new evidence of HDL

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service