C8982

α-Cyano-4-hydroxycinnamic acid

suitable for MALDI-TOF MS

• Synonym(s): α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA
• Linear Formula: HOC₆H₄CH=C(CN)CO₂H
• CAS Number: 28166-41-8
• Molecular Weight: 189.17
• Beilstein: 3271427
• EC Number: 248-879-1
• MDL number: MFCD00004204
• UNSPSC Code: 12352106
• PubChem Substance ID: 24893121
• NACRES: NA.21

Properties

• form: powder
• analyte chemical class(es): glycans, peptides, proteins
• mp: 245-250 °C (lit.)
• suitability: suitable for MALDI-TOF MS
• storage temp.: room temp
• SMILES string: OC(=O)\C(=C\c1ccc(O)cc1)C#N
• InChI: 1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+
• InChI key: AFVLVVWMAFSXCK-VMPITWQZSA-N

Description

General description

α-Cyano-4-hydroxycinnamic acid (CHCA) is specially purified and qualified as a matrix for peptide MALDI-MS (matrix assisted laser desorption ionization-mass spectrometry) calibration standards. CHCA enhances ionization of protein or peptide standards and samples in matrix assisted laser desorption ionization (MALDI) mass spectrometers.
It is also available as part of our ProteoMass^™ MALDI calibration kits (MS-CAL1 and MS-CAL3).

Application

α-Cyano-4-hydroxycinnamic acid has been used as a matrix for MALDI-TOF MS (matrix assisted laser desorption ionization-time of flight mass spectrometry) analysis. The matrix has also been used for sample preparation.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Legal Information

ProteoMass is a trademark of Sigma-Aldrich Co. LLC

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H317
• Precautionary Statements: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1B
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves