Skip to Content
Merck
All Photos(1)

Key Documents

Safety Information

C6749

Sigma-Aldrich

Cytochrome c equine

recombinant, expressed in E. coli

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

CAS Number:
9007-43-6
EC Number:
232-700-9
UNSPSC Code:
12352202
NACRES:
NA.61

biological source

horse

Quality Level

200

recombinant

expressed in E. coli

Assay

≥95% (SDS-PAGE)

form

powder

UniProt accession no.

P00004

storage temp.

−20°C

Gene Information

horse ... CYCS(100053958)

Application

Cytochrome c polymerization occurs by successive domain swapping, which may be a common mechanism of protein polymerization. Cytochrome c has been used in a study to establish that an optimized pulsed-Q dissociation and collision-activated dissociation hybrid workflow may have wide applications in biological and biomedical research.

Biochem/physiol Actions

Cytochrome c has been identified as an important mediator in apoptotic pathways. The release of mitochondrial cytochrome c into the cytoplasm stimulates apoptosis and is commonly used as an indicator of the apoptotic process in the cell.
Cytochrome c is primarily known as an electron-carrying mitochondrial protein. The transition of cytochrome c between the ferrous and ferric states within the cell makes it an efficient biological electron-transporter and it plays a vital role in cellular oxidations in both plants and animals. It is generally regarded as a universal catalyst of respiration, forming an essential electron-bridge between the respirable substrates and oxygen

Preparation Note

Produced using animal component-free materials.

Other Notes

View more information on cytochrome c and electron transport at www.sigma-aldrich.com/enzymeexplorer.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

C6749-10MG-PW:
C6749-VAR:
C6749-10MG:
C6749-50MG-PW:
C6749-50MG:
C6749-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Ramil F Latypov et al.
Journal of molecular biology, 383(2), 437-453 (2008-09-02)
Despite close structural similarity, the ferric and ferrous forms of cytochrome c differ greatly in terms of their ligand binding properties, stability, folding, and dynamics. The reduced heme iron binds diatomic ligands such as CO only under destabilizing conditions that
Ying Dong et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 15(1), 131-139 (2009-01-02)
beta-Lapachone (ARQ 501, a formulation of beta-lapachone complexed with hydroxypropyl-beta-cyclodextrin) is a novel anticancer agent with selectivity against prostate cancer cells overexpressing the NAD(P)H:quinone oxidoreductase-1 enzyme. Lack of solubility and an efficient drug delivery strategy limits this compound in clinical
Tiannan Guo et al.
Journal of proteome research, 7(11), 4831-4840 (2008-10-08)
Coupling of multiplex isobaric tags for relative and absolute quantitation (iTRAQ) to a sensitive linear ion trap (LTQ) mass spectrometer (MS) is a challenging, but highly promising approach for quantitative high-throughput proteomic profiling. Integration of the advantages of pulsed-Q dissociation
Shun Hirota et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(29), 12854-12859 (2010-07-10)
Cytochrome c (cyt c) is a stable protein that functions in a monomeric state as an electron donor for cytochrome c oxidase. It is also released to the cytosol when permeabilization of the mitochondrial outer membrane occurs at the early
Dorival Martins et al.
Frontiers in microbiology, 11, 576708-576708 (2020-10-27)
Stressors and environmental cues shape the physiological state of bacteria, and thus how they subsequently respond to antibiotic toxicity. To understand how superoxide stress can modulate survival to bactericidal antibiotics, we examined the effect of intracellular superoxide generators, paraquat and

Protocols

HPLC Analysis of HPLC Protein Standard on BIOshell™ A400 Protein C4

Separation of HPLC protein standard mixture, analytical standard

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service