C2992

CFTR Inhibitor-172

≥98% (HPLC), powder, CFTR inhibitor

• Synonym(s): 5-[(4-Carboxyphenyl)methylene]-2-thioxo-3-[(3-trifluoromethyl)phenyl-4-thiazolidinone
• Empirical Formula (Hill Notation): C₁₈H₁₀F₃NO₃S₂
• CAS Number: 307510-92-5
• Molecular Weight: 409.40
• MDL number: MFCD06411408
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724436
• NACRES: NA.77

Properties

• product name: CFTR(inh)-172, ≥98% (HPLC), powder
• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: yellow
• solubility: DMSO: ≥10 mg/mL; H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: OC(=O)c1ccc(cc1)\C=C2\SC(=S)N(C2=O)c3cccc(c3)C(F)(F)F
• InChI: 1S/C18H10F3NO3S2/c19-18(20,21)12-2-1-3-13(9-12)22-15(23)14(27-17(22)26)8-10-4-6-11(7-5-10)16(24)25/h1-9H,(H,24,25)/b14-8+
• InChI key: JIMHYXZZCWVCMI-RIYZIHGNSA-N

Description

Application

CFTR(inh)-172 has been used to specifically inhibit cystic fibrosis transmembrane conductance regulator (CFTR) activity. It is also used as a CFTR inhibitor Inh-172 to treat forskolin and IBMX.

Biochem/physiol Actions

CFTR(inh)-172 is an inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR). With a K_i = 300 nM,. CFTR(inh)-172 leads to rapid, reversible and voltage-independent inhibition; it is an antidiarrheal agent in animals. CTFR(inh)-172 may be a useful tool to study animal models of cystic fibrosis and intestinal fluid loss in cholera and other secretory diarrheas. CTFR(inh)-172 is structurally-unrelated to known, but non-specific CFTR inhibitors DPC, NPPB (Cat. No. N4779) and Glibenclamide.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves