C2787

Complement C7 from human serum

≥85% (SDS-PAGE), ≥150,000 C7H50 units/mg protein

• CAS Number: 80295-57-4
• MDL number: MFCD00130845
• UNSPSC Code: 12352205
• NACRES: NA.75

Properties

• biological source: human serum
• Quality Level: 200
• Assay: ≥85% (SDS-PAGE)
• form: solution
• specific activity: ≥150,000 C7H50 units/mg protein
• concentration: 1 mg/mL in 10 mM sodium phosphate, 150 mM sodium chloride, pH 7.2
• technique(s): activity assay: suitable
• UniProt accession no.: P10643
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... C7(730)

Description

Biochem/physiol Actions

The complement system is a complex cascade involving proteolytic cleavage of serum glycoproteins often activated by cell receptors. This cascade ultimately results in induction of the inflammatory response, phagocyte chemotaxis and opsonization, and cell lysis.

A complex of complements C5b, C6, C7, and C8 mediates the polymerization of up to eighteen C9 molecules into a tube-like membrane attack complex that is inserted into the plasma membrane of unwanted organisms, such as of Gram-negative bacteria and viral infected cells. This channel through the lipid bilayer results in lysis of the cell.

Human Complement C7 is a β-2-globulin, which is composed of a single polypeptide chain. The initial binding of C7 and C6 to C5b is thought to form a stable complex for subsequent binding of C8 and C9. The resulting activated complex is responsible for membrane attack and lysis.

Quality

Functionally active by a sensitive hemolytic assay.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable